INT31046

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.44
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Uts2) extracellular region (Uts2)
Anatomy Link Frequency
ileum 1
bladder 1
Uts2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 2 99.70 Very High Very High Very High
tetrodotoxin 4 99.12 Very High Very High Very High
Somatostatin 4 96.72 Very High Very High Very High
Catecholamine 1 83.04 Quite High
noradrenaline 1 80.48 Quite High
conotoxin 1 77.56 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 2 96.60 Very High Very High Very High
Hypertension 2 90.40 High High
Heart Rate Under Development 1 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The urotensin II-induced contraction of the vascular rings was unaffected by pretreatment with tetrodotoxin (1 microM) or indomethacin (14 microM).
Neg (unaffected) Negative_regulation (unaffected) of urotensin II associated with tetrodotoxin
1) Confidence 0.42 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8214148 Disease Relevance 0.17 Pain Relevance 0.14
In both the frog bladder and ileum preparations, the effect of urotensin II was not affected by preincubation of the strips with atropine, tetrodotoxin, and somatostatin-14 but indomethacin produced a significant (P < 0.05) decrease in the strength of the contractions of the bladder (to 21 +/- 6% of control values) and ileum (to 32 +/- 13%).
Negative_regulation (effect) of urotensin II in ileum associated with tetrodotoxin and somatostatin
2) Confidence 0.41 Published 1994 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7883148 Disease Relevance 0 Pain Relevance 0.15
Cardiovascular effects of urotensin II in anesthetized and pithed rats.
Negative_regulation (effects) of urotensin II associated with anesthesia
3) Confidence 0.41 Published 1986 Journal Gen. Comp. Endocrinol. Section Title Doc Link 2879765 Disease Relevance 0.27 Pain Relevance 0.22
Pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) 100 micromol/L did not affect the inhibitory effects of UII (300 nmol/L) on the CSB.
Negative_regulation (effects) of UII
4) Confidence 0.38 Published 2007 Journal Acta Pharmacol. Sin. Section Body Doc Link 17241524 Disease Relevance 0 Pain Relevance 0
Treatment with 1 microM atropine markedly inhibited the urotensin II- and PGF2alpha-induced long-lasting contractions, but was less effective on the PGE2 responses.
Negative_regulation (inhibited) of urotensin II
5) Confidence 0.15 Published 2005 Journal Peptides Section Abstract Doc Link 15629545 Disease Relevance 0 Pain Relevance 0.12
In both the frog bladder and ileum preparations, the effect of urotensin II was not affected by preincubation of the strips with atropine, tetrodotoxin, and somatostatin-14 but indomethacin produced a significant (P < 0.05) decrease in the strength of the contractions of the bladder (to 21 +/- 6% of control values) and ileum (to 32 +/- 13%).
Negative_regulation (effect) of urotensin II in bladder associated with tetrodotoxin and somatostatin
6) Confidence 0.14 Published 1994 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 7883148 Disease Relevance 0 Pain Relevance 0.15

General Comments

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