INT310469

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dlx2) nucleus (Dlx2) DNA binding (Dlx2)
Anatomy Link Frequency
neuronal 4
Dlx2 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 80 81.08 Quite High
interneuron 16 54.84 Quite High
Action potential 14 46.80 Quite Low
cerebral cortex 56 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 74 95.96 Very High Very High Very High
Neurodegenerative Disease 36 83.20 Quite High
Stuttering 4 40.00 Quite Low
Injury 22 5.00 Very Low Very Low Very Low
Stab Wounds 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 4 5.00 Very Low Very Low Very Low
Brain Injury 4 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon forced expression of Dlx2, a substantial number of postnatal cortical astroglia were redirected towards a neuronal identity as revealed by ?
Negative_regulation (redirected) of Gene_expression (expression) of Dlx2 in neuronal
1) Confidence 0.39 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.32 Pain Relevance 0.11
Taken together, these data show that some postnatal cortical astroglia can be redirected by forced expression of Dlx2 towards a neuronal identity; however, in sharp contrast to the progressive maturation of Neurog2-transduced cells, most of the astroglia-derived neurons reprogrammed by Dlx2 remain in a rather immature state, suggesting a comparatively less efficient reprogramming by Dlx2.
Negative_regulation (redirected) of Gene_expression (expression) of Dlx2 in neuronal
2) Confidence 0.39 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.35 Pain Relevance 0.05

General Comments

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