INT31047

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Context Info
Confidence 0.75
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.84
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HRH2) signal transducer activity (HRH2)
HRH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 26 100.00 Very High Very High Very High
methadone 2 91.88 High High
Potency 2 89.44 High High
abdominal pain 1 87.08 High High
peptic ulcer disease 2 86.48 High High
cocaine 1 86.32 High High
Morphine 6 85.96 High High
Neurobehavioral 1 83.68 Quite High
withdrawal 1 79.84 Quite High
Inflammation 1 66.20 Quite High
Disease Link Frequency Relevance Heat
Ulcers 11 100.00 Very High Very High Very High
Galactorrhea 124 98.60 Very High Very High Very High
Duodenal Obstruction 2 92.88 High High
Disease 8 92.32 High High
Peritonitis 2 91.40 High High
Bruxism 1 88.44 High High
Abdominal Pain 1 87.08 High High
Syndrome 2 82.40 Quite High
Death 1 79.36 Quite High
INFLAMMATION 1 66.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antacids and type 2 histamine receptor antagonists are used most often to neutralise or decrease acid secretion, respectively.
Localization (secretion) of type 2 histamine receptor associated with antagonist
1) Confidence 0.75 Published 1986 Journal Equine Vet. J. Section Abstract Doc Link 3758011 Disease Relevance 1.20 Pain Relevance 0.17
This is the first reported case of gastric acid secretion resistant to an H-2 receptor antagonist in a clinical, rather than experimental, setting.
Localization (secretion) of H-2 receptor associated with antagonist
2) Confidence 0.71 Published 1980 Journal Ann. Intern. Med. Section Abstract Doc Link 7387019 Disease Relevance 0.26 Pain Relevance 0.14
The actions of a single bedtime (21:00 hour) dose of the H2 receptor antagonists nizatidine (150 mg and 300 mg), ranitidine (300 mg) and cimetidine (800 mg), as well as placebo on nocturnal gastric acid and volume secretion (01:00 to 07:00 hours, and on overall 24 hour H+ ion concentration were studied.
Localization (secretion) of H2 receptor associated with antagonist
3) Confidence 0.32 Published 1986 Journal Hepatogastroenterology Section Abstract Doc Link 2879782 Disease Relevance 0 Pain Relevance 0.13
Although histamine H2-receptor competitive antagonists cimetidine and ranitidine, used in active ulcers, ulcer prophylaxis and gastric hypersecretory conditions, have stimulatory effect on prolactin secretion (Perret et al 1986; Knigge 1990), hyperprolactinemia has never been systematically reported, except for isolated case reports published shortly after the approval of the drugs (Petrillo et al 1977).
Localization (secretion) of H2-receptor associated with galactorrhea, antagonist and ulcers
4) Confidence 0.22 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.38 Pain Relevance 0.94
The actions of a single bedtime (2100 h) dose of the H2-receptor antagonist nizatidine (150 mg and 300 mg), ranitidine (300 mg), cimetidine (800 mg), and famotidine (40 mg), as well as placebo on nocturnal gastric acid and volume secretion (2400 to 0600 h) and on overall 24 h H+-ion concentration were studied.
Localization (secretion) of H2-receptor associated with antagonist
5) Confidence 0.13 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2892256 Disease Relevance 0 Pain Relevance 0.14

General Comments

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