INT310471

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ascl1) nucleus (Ascl1)
Anatomy Link Frequency
interneuron 1
neural 1
Ascl1 (Mus musculus)
Pain Link Frequency Relevance Heat
interneuron 16 95.40 Very High Very High Very High
Potency 4 79.48 Quite High
GABAergic 80 64.44 Quite High
projection neuron 2 34.40 Quite Low
cerebral cortex 56 26.08 Quite Low
imagery 20 5.00 Very Low Very Low Very Low
Action potential 14 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 36 78.24 Quite High
Epilepsy 2 56.04 Quite High
Stuttering 4 55.48 Quite High
Injury 22 24.32 Low Low
Infection 74 5.00 Very Low Very Low Very Low
Stab Wounds 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 4 5.00 Very Low Very Low Very Low
Brain Injury 4 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed culturing neural cells of different origins under neurosphere conditions has been shown to induce a partial loss of region-specific transcription factor expression while resulting in the up-regulation of Olig2 and Mash1 [34], providing a more permissive transcriptional environment that favours reprogramming towards distinct neuronal subtypes.
Regulation (regulation) of Mash1 in neural
1) Confidence 0.34 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.06 Pain Relevance 0.06
Importantly, while being upstream of Dlx2, which is a direct transcriptional target of Mash1 [30], the latter factor is also known to activate targets that are not shared with Dlx2, suggesting that complete interneuron specification may require the activity of both factors [31],[32].
Regulation (target) of Mash1 in interneuron associated with interneuron
2) Confidence 0.18 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.13 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox