INT310474

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Fate1) molecular_function (Fate1) biological_process (Fate1)
Anatomy Link Frequency
neuronal 4
Fate1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 6 97.40 Very High Very High Very High
GABAergic 80 92.72 High High
cerebral cortex 56 80.64 Quite High
imagery 20 5.00 Very Low Very Low Very Low
interneuron 16 5.00 Very Low Very Low Very Low
Action potential 14 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 36 74.96 Quite High
Brain Injury 4 42.72 Quite Low
Injury 22 25.00 Low Low
Infection 74 5.00 Very Low Very Low Very Low
Stab Wounds 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Stuttering 4 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 4 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Towards this end, we first aimed at a more potent neuronal reprogramming by inducing higher and more persistent expression of neurogenic fate determinants in astroglial cells.
Positive_regulation (inducing) of Gene_expression (expression) of fate in neuronal
1) Confidence 0.04 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.17
Importantly, the neurotransmitter fate choice of astroglia-derived neurons can be controlled by selective expression of distinct neurogenic transcription factors: forced expression of the dorsal telencephalic fate determinant neurogenin-2 (Neurog2) directs cortical astroglia to generate synapse-forming glutamatergic neurons; in contrast, the ventral telencephalic fate determinant Dlx2 induces a GABAergic identity, although the overall efficiency of Dlx2-mediated neuronal reprogramming is much lower compared to Neurog2, suggesting that cortical astroglia possess a higher competence to respond to the dorsal telencephalic fate determinant.
Positive_regulation (forced) of Gene_expression (expression) of fate in neuronal associated with neurotransmitter and gabaergic
2) Confidence 0.04 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2872647 Disease Relevance 0.07 Pain Relevance 0.16

General Comments

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