INT310476

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.71
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurog2) nucleus (Neurog2) DNA binding (Neurog2)
Anatomy Link Frequency
neuronal 2
Neurog2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 30 84.20 Quite High
cerebral cortex 84 77.68 Quite High
GABAergic 120 47.12 Quite Low
Glutamate 9 32.00 Quite Low
gABA 6 24.80 Low Low
interneuron 24 5.00 Very Low Very Low Very Low
Action potential 21 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 54 99.68 Very High Very High Very High
Leukemia 3 91.04 High High
Infection 111 84.24 Quite High
Injury 33 67.56 Quite High
Brain Injury 6 54.04 Quite High
Targeted Disruption 9 50.48 Quite High
Stab Wounds 15 5.00 Very Low Very Low Very Low
Stuttering 6 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 6 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, these viral vectors are prone to silencing [18] and we observed a severe decrease in Neurog2 or green fluorescent protein (GFP) reporter expression already 7–14 d after transduction [7],[19].
Negative_regulation (decrease) of Gene_expression (expression) of Neurog2
1) Confidence 0.40 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.21 Pain Relevance 0.09
In agreement with our previous observation on the high efficiency of neurogenesis from astroglia following forced Neurog2 expression, the vast majority of Neurog2-transduced astroglia had differentiated into ?
Negative_regulation (following) of Gene_expression (expression) of Neurog2 associated with neurodegenerative disease
2) Confidence 0.35 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.34 Pain Relevance 0.07
47 imaged neurons, 3 independent experiments) exhibited Ca2+ transients at 14–43 d after transduction with Neurog2, thus indicating the high degree of incorporation of Neurog2-transduced astroglia into excitatory neuronal networks.
Negative_regulation (exhibited) of Gene_expression (transduction) of Neurog2 in neuronal
3) Confidence 0.35 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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