INT310477

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dlx2) nucleus (Dlx2) DNA binding (Dlx2)
Anatomy Link Frequency
neurons 2
Dlx2 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 80 78.72 Quite High
cerebral cortex 56 66.64 Quite High
interneuron 16 66.32 Quite High
Spinal cord 2 51.76 Quite High
antagonist 8 25.76 Quite Low
imagery 20 5.00 Very Low Very Low Very Low
Action potential 14 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 74 97.24 Very High Very High Very High
Neurodegenerative Disease 36 80.56 Quite High
Stuttering 4 42.64 Quite Low
Injury 22 5.00 Very Low Very Low Very Low
Stab Wounds 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 4 5.00 Very Low Very Low Very Low
Brain Injury 4 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with a more mature status, a higher proportion of Mash1/Dlx2 co-expressing neurons exhibited specific interneuronal firing patterns (6 out of 15 cells recorded, Figure 8 and Figure 9A–9A”) compared to Dlx2 (8 out of 30 cells recorded, Figure 8).
Positive_regulation (proportion) of Dlx2 in neurons
1) Confidence 0.46 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.47 Pain Relevance 0.09
In contrast to reprogramming induced by Neurog2 that occurred with very high efficiency, only a third of all Dlx2-transduced astroglia differentiated into neurons and most of these exhibited high input resistances typical of immature neurons even after prolonged periods of culturing.
Positive_regulation (third) of Dlx2-transduced in neurons
2) Confidence 0.46 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.14

General Comments

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