INT310530

Context Info Confidence 0.49 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 10 Disease Relevance 4.16 Pain Relevance 0.28

extracellular region (HAMP) cytoplasm (HAMP)

Anatomy Link Frequency liver 2 HAMP (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 18 99.32 cytokine 6 98.98 Pain 12 28.80 fibrosis 16 5.00 imagery 4 5.00 Parenteral administration 2 5.00 headache 2 5.00

Disease Link Frequency Relevance Heat Sickle Cell Anemia 172 99.84 Hypoxia 10 99.40 INFLAMMATION 18 99.32 Anaemia 100 99.22 Reperfusion Injury 2 87.80 Infection 14 86.64 Hepatocellular Cancer 24 85.60 Leukemia 8 85.44 Iron Overload 104 82.44 Cytomegalovirus Infection 24 82.00

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By analogy with the anemia of chronic inflammation (in which cytokines increase hepcidin levels), one may speculate that hepcidin levels would be elevated in SCD.

Positive_regulation (elevated) of Gene_expression (levels) of hepcidin associated with sickle cell anemia, anaemia, inflammation and cytokine

1) Confidence 0.49 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 2.10 Pain Relevance 0.14

Anemia, hypoxia, and erythropoiesis decrease hepcidin gene expression, thereby stabilizing ferroportin and increasing circulating iron available for erythropoiesis [6].

Positive_regulation (stabilizing) of Gene_expression (expression) of hepcidin associated with anaemia and hypoxia

2) Confidence 0.45 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 0.58 Pain Relevance 0.09

Since this disorder is hallmarked by increased hepcidin expression, we analysed urinary hepcidin levels in the patient compared with four age-matched healthy male donors.

Positive_regulation (increased) of Gene_expression (expression) of hepcidin

3) Confidence 0.17 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.09 Pain Relevance 0

Relative hepcidin mRNA expression was normalized to GAPDH (glyceraldehyde-3-phosphate dehydrogenase) mRNA.

Positive_regulation (normalized) of Gene_expression (expression) of hepcidin mRNA

4) Confidence 0.13 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.21 Pain Relevance 0

TMPRSS6(Y141C) overexpression increases hepcidin mRNA expression

Positive_regulation (increases) of Gene_expression (expression) of hepcidin mRNA

5) Confidence 0.13 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.15 Pain Relevance 0

Hepcidin is a small peptide hormone produced by the liver in response to iron levels, inflammatory signals, hypoxia and the erythropoietic drive.

Positive_regulation (response) of Gene_expression (produced) of Hepcidin in liver associated with inflammation and hypoxia

6) Confidence 0.13 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.26 Pain Relevance 0.05

As a consequence, hepcidin mRNA expression is increased, causing the clinical symptoms observed in this IRIDA patient.

Positive_regulation (causing) of Gene_expression (expression) of hepcidin mRNA

7) Confidence 0.12 Published 2010 Journal Biochemical Journal Section Abstract Doc Link PMC2958558 Disease Relevance 0.22 Pain Relevance 0

As a consequence, hepcidin mRNA expression is increased, causing the clinical symptoms observed in this IRIDA patient.

Positive_regulation (increased) of Gene_expression (expression) of hepcidin mRNA

8) Confidence 0.12 Published 2010 Journal Biochemical Journal Section Abstract Doc Link PMC2958558 Disease Relevance 0.22 Pain Relevance 0

After 24 h, the cells were transfected with 200 ng of pGL3-hepcidin(WT_2.7Kb) reporter vector containing 2.7 kb of the 5?

Positive_regulation (transfected) of Gene_expression (transfected) of pGL3-hepcidin

9) Confidence 0.11 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.24 Pain Relevance 0

Urinary hepcidin levels are elevated in the IRIDA patient

Positive_regulation (elevated) of Gene_expression (levels) of hepcidin

10) Confidence 0.11 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.10 Pain Relevance 0

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