INT310530

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 4.16
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HAMP) cytoplasm (HAMP)
Anatomy Link Frequency
liver 2
HAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 99.32 Very High Very High Very High
cytokine 6 98.98 Very High Very High Very High
Pain 12 28.80 Quite Low
fibrosis 16 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 172 99.84 Very High Very High Very High
Hypoxia 10 99.40 Very High Very High Very High
INFLAMMATION 18 99.32 Very High Very High Very High
Anaemia 100 99.22 Very High Very High Very High
Reperfusion Injury 2 87.80 High High
Infection 14 86.64 High High
Hepatocellular Cancer 24 85.60 High High
Leukemia 8 85.44 High High
Iron Overload 104 82.44 Quite High
Cytomegalovirus Infection 24 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By analogy with the anemia of chronic inflammation (in which cytokines increase hepcidin levels), one may speculate that hepcidin levels would be elevated in SCD.
Positive_regulation (elevated) of Gene_expression (levels) of hepcidin associated with sickle cell anemia, anaemia, inflammation and cytokine
1) Confidence 0.49 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 2.10 Pain Relevance 0.14
Anemia, hypoxia, and erythropoiesis decrease hepcidin gene expression, thereby stabilizing ferroportin and increasing circulating iron available for erythropoiesis [6].
Positive_regulation (stabilizing) of Gene_expression (expression) of hepcidin associated with anaemia and hypoxia
2) Confidence 0.45 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 0.58 Pain Relevance 0.09
Since this disorder is hallmarked by increased hepcidin expression, we analysed urinary hepcidin levels in the patient compared with four age-matched healthy male donors.
Positive_regulation (increased) of Gene_expression (expression) of hepcidin
3) Confidence 0.17 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.09 Pain Relevance 0
Relative hepcidin mRNA expression was normalized to GAPDH (glyceraldehyde-3-phosphate dehydrogenase) mRNA.
Positive_regulation (normalized) of Gene_expression (expression) of hepcidin mRNA
4) Confidence 0.13 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.21 Pain Relevance 0
TMPRSS6(Y141C) overexpression increases hepcidin mRNA expression
Positive_regulation (increases) of Gene_expression (expression) of hepcidin mRNA
5) Confidence 0.13 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.15 Pain Relevance 0
Hepcidin is a small peptide hormone produced by the liver in response to iron levels, inflammatory signals, hypoxia and the erythropoietic drive.
Positive_regulation (response) of Gene_expression (produced) of Hepcidin in liver associated with inflammation and hypoxia
6) Confidence 0.13 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.26 Pain Relevance 0.05
As a consequence, hepcidin mRNA expression is increased, causing the clinical symptoms observed in this IRIDA patient.
Positive_regulation (causing) of Gene_expression (expression) of hepcidin mRNA
7) Confidence 0.12 Published 2010 Journal Biochemical Journal Section Abstract Doc Link PMC2958558 Disease Relevance 0.22 Pain Relevance 0
As a consequence, hepcidin mRNA expression is increased, causing the clinical symptoms observed in this IRIDA patient.
Positive_regulation (increased) of Gene_expression (expression) of hepcidin mRNA
8) Confidence 0.12 Published 2010 Journal Biochemical Journal Section Abstract Doc Link PMC2958558 Disease Relevance 0.22 Pain Relevance 0
After 24 h, the cells were transfected with 200 ng of pGL3-hepcidin(WT_2.7Kb) reporter vector containing 2.7 kb of the 5?
Positive_regulation (transfected) of Gene_expression (transfected) of pGL3-hepcidin
9) Confidence 0.11 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.24 Pain Relevance 0
Urinary hepcidin levels are elevated in the IRIDA patient
Positive_regulation (elevated) of Gene_expression (levels) of hepcidin
10) Confidence 0.11 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.10 Pain Relevance 0

General Comments

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