INT310549

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.17
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (ERLIN1)
Anatomy Link Frequency
plasma 2
ERLIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 15 82.64 Quite High
anesthesia 5 13.44 Low Low
lidocaine 5 5.00 Very Low Very Low Very Low
Lasting pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 10 92.44 High High
Unconsciousness 10 24.56 Low Low
Body Weight 15 8.08 Low Low
Acid Reflux 5 5.00 Very Low Very Low Very Low
Neurological Disease 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This time course of the concentration of the effect site and the plasma is explained by the plasma and effect site equilibrium rate constant, ke0, which is incorporated into the TCI system with various compartmental models of propofol.
Positive_regulation (incorporated) of ke0 in plasma
1) Confidence 0.05 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0
Adequate ke0 for a specific PK model will predict an accurate time course of concentration, and will be used for better control of the effect site concentration during targeting of the effect site.



Positive_regulation (used) of ke0
2) Confidence 0.05 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0.17 Pain Relevance 0.04
Second, the influence of gender on pharmacokinetics and pharmacodynamics could be considered as a significant cause for the difference of ke0.
Positive_regulation (cause) of ke0
3) Confidence 0.05 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0.03
Therefore, we sought to determine a ke0 value that could minimize the total discrepancy (TD) between the inputted ke0 and the calculated ke0.
Positive_regulation (calculated) of ke0
4) Confidence 0.05 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0
We investigated the method for calculation of ke0 derived from t1/2ke0, which is ln2/ke0, at which the effect-site concentration becomes half of the target plasma concentration with a certain probability of LOR.
Spec (investigated) Positive_regulation (calculation) of ke0 in plasma
5) Confidence 0.05 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0

General Comments

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