INT31060

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.65
Pain Relevance 7.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
brains 4
hypothalamus 2
putamen 2
sympathetic 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 145 100.00 Very High Very High Very High
Opioid 32 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
opiate 16 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
Opioid receptor 1 1 100.00 Very High Very High Very High
positron emission tomography 12 99.50 Very High Very High Very High
Pain 208 99.48 Very High Very High Very High
midbrain 2 98.00 Very High Very High Very High
Fibrositis 298 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 209 99.48 Very High Very High Very High
Fibromyalgia 300 97.84 Very High Very High Very High
Low Back Pain 8 96.24 Very High Very High Very High
Death 1 88.60 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

48 77.92 Quite High
Cocaine Dependence 3 77.04 Quite High
Neuroblastoma 3 75.00 Quite High
Neuropathic Pain 8 61.00 Quite High
Hyperalgesia 4 60.44 Quite High
Bordatella Infection 1 58.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Initiation of OPRM1 at the upstream site decreases the initiation at the main AUG site.
Negative_regulation (decreases) of OPRM1 Binding (Initiation) of
1) Confidence 0.37 Published 2009 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 19609488 Disease Relevance 0 Pain Relevance 0.25
Inactivation by thiol reducing and alkylating agents of ligand binding to the human mu-opioid receptor was examined.
Negative_regulation (reducing) of mu-opioid receptor Binding (binding) of associated with opioid receptor
2) Confidence 0.36 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9187354 Disease Relevance 0 Pain Relevance 0.23
Marked reductions in the levels of enkephalin mRNA and mu opiate receptor binding were found in the caudate and putamen, concomitant with elevations in levels of dynorphin mRNA and kappa opiate receptor binding in the putamen and caudate, respectively.
Negative_regulation (reductions) of mu opiate receptor Binding (binding) of in putamen associated with dynorphin, opioid receptor 1, opiate and enkephalin
3) Confidence 0.35 Published 1993 Journal Synapse Section Abstract Doc Link 7683144 Disease Relevance 0.23 Pain Relevance 0.98
Pretreatment with the mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO), or the ORL1 receptor agonist, orphanin FQ/nociceptin desensitized both mu-opioid and ORL1 receptor responses. beta-Funaltrexamine (beta-FNA) pretreatment also blocked both mu-opioid and ORL1 receptor responses, but only mu-opioid receptor binding was reduced.
Negative_regulation (reduced) of mu-opioid receptor Binding (binding) of associated with orphanin, agonist, enkephalin, opioid receptor and opioid
4) Confidence 0.28 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940375 Disease Relevance 0.07 Pain Relevance 0.79
Endomorphin-1 and -2 inhibit human vascular sympathetic norepinephrine release: lack of interaction with mu 3 opiate receptor subtype.
Negative_regulation (inhibit) of mu 3 opiate receptor Binding (interaction) of in sympathetic associated with opiate
5) Confidence 0.27 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 10375796 Disease Relevance 0 Pain Relevance 0.20
In addition, antagonist-induced increases in adenylate cyclase activity were observed only after chronic PLO17 administration.2+ Finally, chronic pretreatment of cells with PLO17 (10 microM) resulted in a significant decrease in mu opioid, but not delta opioid receptor, binding, whereas treatment with DPDPE (0.3 microM) resulted in a significant decrease in delta opioid, but not mu opioid receptor binding.
Negative_regulation (decrease) of mu opioid receptor Binding (binding) of associated with antagonist, mu opioid receptor, opioid receptor and opioid
6) Confidence 0.16 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8035314 Disease Relevance 0.13 Pain Relevance 0.86
Moreover, PET data show that baseline mu-opioid receptor binding is decreased in multiple pain processing regions in the brains of fibromyalgia patients, consistent with either increased release of endogenous mu-opioid ligands in fibromyalgia or reduced numbers of receptors (Harris et al 2007).
Negative_regulation (decreased) of mu-opioid receptor Binding (binding) of in brains associated with pain, opioid receptor, opioid and fibrositis
7) Confidence 0.12 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643113 Disease Relevance 1.04 Pain Relevance 1.42
Moreover, positron emission tomography data show that baseline mu-opioid receptor binding is decreased in multiple pain processing regions in the brains of fibromyalgia patients, consistent with the hypothesis that there is increased release of endogenous mu-opioid ligands or reduced receptor number in fibromyalgia leading to high baseline occupancy of the receptors (Harris et al 2007).
Negative_regulation (decreased) of mu-opioid receptor Binding (binding) of in brains associated with pain, positron emission tomography, opioid receptor, opioid and fibrositis
8) Confidence 0.12 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643113 Disease Relevance 1.01 Pain Relevance 1.37
The fact that inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 prevents MOR internalization induced by H2S but not by DAMGO, indicates that H2S directly activates the PI3K/AKT pathway and that activation of this pathway is hierarchically higher in the mechanism that leads to MOR activation by H2S.
Negative_regulation (prevents) of MOR Binding (internalization) of associated with opioid receptor
9) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.38
Tyr-W-MIF-1 prefers a transPro 2-5 turn, and an additional N-terminal Phe severely inhibits mu-opiate receptor binding.
Negative_regulation (inhibits) of mu-opiate receptor Binding (binding) of associated with opiate
10) Confidence 0.05 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10676465 Disease Relevance 0 Pain Relevance 0.30
Serotonergic lesions decrease mu- and delta-opiate receptor binding in discrete areas of the hypothalamus and in the midbrain central gray.
Negative_regulation (decrease) of delta-opiate receptor Binding (binding) of in hypothalamus associated with midbrain and opiate
11) Confidence 0.03 Published 1993 Journal Brain Res. Section Title Doc Link 8275308 Disease Relevance 0 Pain Relevance 0.43
The results indicate that at relatively high concentrations Tyr-MIF-1, like ACTH, can affect binding to the opiate receptor, but unlike ACTH, binding of Tyr-MIF-1 appears relatively selective for the mu site.
Negative_regulation (affect) of opiate receptor Binding (binding) of associated with opiate
12) Confidence 0.01 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2880352 Disease Relevance 0 Pain Relevance 0.53

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox