INT310679

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ARSB) Golgi apparatus (ARSB) lysosome (ARSB)
ARSB (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 6 84.76 Quite High
Spinal cord 16 5.00 Very Low Very Low Very Low
cva 16 5.00 Very Low Very Low Very Low
intrathecal 12 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mucopolysaccharidoses 276 100.00 Very High Very High Very High
Blindness 6 92.44 High High
Optic Atrophy 6 91.88 High High
Hydrocephalus 10 91.04 High High
Pathologic Constriction 10 89.88 High High
Umbilical Hernia 4 81.36 Quite High
Disease 104 80.00 Quite High
Carpal Tunnel Syndrome 8 79.68 Quite High
Apnoea 12 78.36 Quite High
Hearing Impairment 10 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over 130 ARSB mutations have been reported, causing absent or reduced arylsulfatase B (N-acetylgalactosamine 4-sulfatase) activity and interrupted dermatan sulfate and chondroitin sulfate degradation.
Positive_regulation (causing) of arylsulfatase B
1) Confidence 0.39 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2873242 Disease Relevance 1.74 Pain Relevance 0.04
Although no specific ethnic group has been associated with an increased risk of MPS VI, some populations have been found to have increased frequencies of specific mutations.
Positive_regulation (increased) of MPS VI associated with mucopolysaccharidoses
2) Confidence 0.39 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2873242 Disease Relevance 0.62 Pain Relevance 0

General Comments

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