INT310697

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 6
Disease Relevance 1.34
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Ptger2) plasma membrane (Tlr4, Ptger2) intracellular (Tlr4)
signal transducer activity (Ptger2) cytoplasm (Tlr4)
Anatomy Link Frequency
PGE2 4
Tlr4 (Mus musculus)
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 10 97.12 Very High Very High Very High
fibrosis 35 86.40 High High
Inflammation 124 79.20 Quite High
cytokine 18 5.00 Very Low Very Low Very Low
COX-2 inhibitor 10 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 16 95.84 Very High Very High Very High
Sprains And Strains 6 93.88 High High
Cystic Fibrosis 35 86.40 High High
Bacterial Infection 31 80.44 Quite High
INFLAMMATION 107 79.20 Quite High
Pseudomonas Infection 3 75.00 Quite High
Stress 35 46.84 Quite Low
Injury 30 5.00 Very Low Very Low Very Low
Vasculitis 20 5.00 Very Low Very Low Very Low
Sepsis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS induced lower airway constriction and PGE2 production in cPLA2?
LPS Positive_regulation (induced) of Gene_expression (production) of PGE2 in PGE2
1) Confidence 0.03 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2873258 Disease Relevance 0.79 Pain Relevance 0.38
We found that LPS-induced COX-2 expression and PGE2 production were mediated through NF-?
LPS Positive_regulation (induced) of Gene_expression (production) of PGE2
2) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3002338 Disease Relevance 0.22 Pain Relevance 0
B (p65) activation, COX-2 expression, and PGE2 production induced by LPS.


LPS Positive_regulation (induced) of Gene_expression (production) of PGE2
3) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3002338 Disease Relevance 0.15 Pain Relevance 0
LPS induces COX-2 expression and PGE2 synthesis in bEnd.3 cells
LPS Positive_regulation (induces) of Gene_expression (synthesis) of PGE2
4) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0
Cultured bEnd.3 cells were used to investigate LPS-induced COX-2 expression and PGE2 production.
LPS Positive_regulation (induced) of Gene_expression (production) of PGE2 in PGE2
5) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC3002338 Disease Relevance 0.18 Pain Relevance 0
As shown in Figure 4A, pretreatment with CoPP attenuated LPS-induced COX-2 protein expression and PGE2 synthesis.
LPS Positive_regulation (induced) of Gene_expression (synthesis) of PGE2
6) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0 Pain Relevance 0

General Comments

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