INT310728

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (DKC1) cell proliferation (DKC1) nucleoplasm (DKC1)
nucleolus (DKC1) RNA binding (DKC1) nucleus (DKC1)
Anatomy Link Frequency
bone marrow 1
telomere 1
DKC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 154 97.72 Very High Very High Very High
Inflammation 8 5.00 Very Low Very Low Very Low
peptic ulcer disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neutrophil Disorders 34 100.00 Very High Very High Very High
Liver Disease 10 100.00 Very High Very High Very High
Disease 38 99.14 Very High Very High Very High
Syndrome 4 98.04 Very High Very High Very High
Pulmonary Fibrosis 136 97.72 Very High Very High Very High
Cancer 8 87.52 High High
Pulmonary Disease 14 85.68 High High
Respiratory Failure 4 80.12 Quite High
Death 12 78.48 Quite High
Cicatrix 2 46.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This disease can be considered a “telomeropathy,” like DKC, bone marrow failure and liver disease, when caused by germline mutations in telomerase and characterized by short telomere lengths.
DKC Binding (characterized) of in telomere associated with liver disease, disease and neutrophil disorders
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 1.45 Pain Relevance 0.33
Mutations in the genes encoding the telomerase complex were first found in patients with dyskeratosis congenita (DKC), and then in patients with bone marrow failure syndromes, pulmonary fibrosis and liver disease.
DKC Binding (found) of in bone marrow associated with liver disease, fibrosis, syndrome, pulmonary fibrosis and neutrophil disorders
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 0.91 Pain Relevance 0.05

General Comments

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