INT31073

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Context Info
Confidence 0.27
First Reported 1987
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.55
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
Dismenorea 1 96.84 Very High Very High Very High
opiate 2 89.20 High High
narcan 4 86.96 High High
endometriosis 1 77.72 Quite High
Opioid 4 75.00 Quite High
iatrogenic 1 75.00 Quite High
dopamine receptor 1 40.56 Quite Low
antagonist 1 39.12 Quite Low
Disease Link Frequency Relevance Heat
Galactorrhea 8 99.32 Very High Very High Very High
Reprotox - General 1 4 97.40 Very High Very High Very High
Growth Problems 1 95.92 Very High Very High Very High
Functional Bowel Disorder 1 95.32 Very High Very High Very High
Polycystic Ovary Syndrome 1 94.28 High High
Disease 3 93.20 High High
Precocious Puberty 1 79.56 Quite High
Uterine Fibroids 1 78.44 Quite High
Endometriosis (extended) 2 77.72 Quite High
Pituitary Cancer 1 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mounting evidence suggests that GnRH agonist suppression of serum gonadotropins may also be important in many of the clinical applications described above.
Regulation (important) of Negative_regulation (suppression) of GnRH associated with agonist
1) Confidence 0.27 Published 2007 Journal Expert Opin Investig Drugs Section Abstract Doc Link 17970643 Disease Relevance 0.85 Pain Relevance 0.22
The involvement of endogenous opioid peptides in the inhibition of GnRH release as a central factor leading to the hypogonadotropic state has been recently described.
Regulation (involvement) of Negative_regulation (inhibition) of GnRH associated with endogenous opioid
2) Confidence 0.06 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2880862 Disease Relevance 0.70 Pain Relevance 0.40

General Comments

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