INT310747

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (JAK2) cytosol (JAK2) signal transduction (JAK2)
histone binding (JAK2) cytoskeleton (JAK2) nucleus (JAK2)
Anatomy Link Frequency
blood 1
JAK2 (Homo sapiens)
JAK2 - V617F (1)
Pain Link Frequency Relevance Heat
cytokine 3 90.28 High High
palliative 2 11.16 Low Low
chemokine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 53 98.80 Very High Very High Very High
Myeloproliferative Disorder 45 93.20 High High
Myelofibrosis 30 84.36 Quite High
Systemic Mastocytosis 5 79.60 Quite High
Disease 9 73.68 Quite High
Cancer 9 66.48 Quite High
Hypereosinophilic Syndrome 3 65.36 Quite High
Chronic Neutrophilic Leukemia 7 62.64 Quite High
Myeloid Leukemia 26 62.04 Quite High
Gastritis 2 54.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mutation occurs in a highly conserved region of the pseudokinase domain that is believed to negatively regulate JAK2 signaling.
Regulation (regulate) of JAK2
1) Confidence 0.33 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.29 Pain Relevance 0.05
His peripheral blood was negative for the JAK2 V617F point mutation, and showed normal expression of CD55 and CD59.
Regulation (negative) of JAK2 (V617F) in blood
2) Confidence 0.20 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2873355 Disease Relevance 0.30 Pain Relevance 0

General Comments

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