INT310812

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
T cells 2
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 55.04 Quite High
cytokine 40 28.36 Quite Low
Inflammation 30 28.00 Quite Low
withdrawal 5 5.00 Very Low Very Low Very Low
Spontaneous pain 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
IPN 3 5.00 Very Low Very Low Very Low
allodynia 2 5.00 Very Low Very Low Very Low
Brush evoked pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1 55.04 Quite High
Diabetes Mellitus 1 53.84 Quite High
Autoimmune Disease 1 53.08 Quite High
Targeted Disruption 1 50.00 Quite Low
INFLAMMATION 35 28.00 Quite Low
Leukemia 1 16.88 Low Low
Pain 8 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been also demonstrated that the FERM (band 4.1, ezrin, radixin, moesin) domain of PTPH1 is necessary for the inhibition of Mek, Erk, Jnk and AP-1 and also for localization of the phosphatase on the plasma membrane of Jurkat T cells [14].
Positive_regulation (necessary) of Negative_regulation (inhibition) of AP-1 in T cells
1) Confidence 0.11 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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