INT310883

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 6.27
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

53T (Mus musculus)
53T - A53T (4)
Pain Link Frequency Relevance Heat
anesthesia 8 98.88 Very High Very High Very High
midbrain 52 96.08 Very High Very High Very High
Spinal cord 68 89.52 High High
medulla 108 88.88 High High
Hippocampus 4 87.96 High High
cerebral cortex 32 86.64 High High
Inflammation 16 73.12 Quite High
Glutamate 20 57.12 Quite High
cytokine 20 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 464 100.00 Very High Very High Very High
Movement Disorders 12 99.40 Very High Very High Very High
Motor Neuron Diseases 12 94.48 High High
Paralysis 52 93.64 High High
Disease 108 93.44 High High
Lifespan 16 90.56 High High
Disease Progression 8 87.16 High High
Body Weight 12 84.40 Quite High
Congenital Anomalies 16 81.04 Quite High
INFLAMMATION 36 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-syn on the neurological dysfunction, a cohort of A53T mice were administered with doxycycline (DOX), a tetracycline derivative, to block the expression of A53T ?
Negative_regulation (block) of Gene_expression (expression) of A53T (A53T) associated with targeted disruption and anesthesia
1) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.64 Pain Relevance 0.10
To assess the impact of developmental expression of A53T ?
Negative_regulation (developmental) of Gene_expression (expression) of A53T (A53T) associated with targeted disruption
2) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.52 Pain Relevance 0.10
It is rather surprising to find that over-expression of A53T ?
Negative_regulation (surprising) of Gene_expression (expression) of A53T (A53T) associated with targeted disruption
3) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.33 Pain Relevance 0.34
Moreover, at the cellular level, the expression of A53T ?
Negative_regulation (Moreover) of Gene_expression (expression) of A53T (A53T) associated with targeted disruption
4) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.78 Pain Relevance 0.22

General Comments

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