INT310892

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 6.77
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

53T (Mus musculus)
53T - A53T (4)
Pain Link Frequency Relevance Heat
cerebral cortex 32 92.08 High High
anesthesia 8 91.52 High High
midbrain 52 89.92 High High
Hippocampus 4 89.12 High High
medulla 108 87.12 High High
Spinal cord 68 86.00 High High
cytokine 20 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
Glutamate 20 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 464 100.00 Very High Very High Very High
Paralysis 52 99.38 Very High Very High Very High
Congenital Anomalies 16 96.56 Very High Very High Very High
Lifespan 16 96.40 Very High Very High Very High
Body Weight 12 94.00 High High
Disease 108 71.32 Quite High
Disease Progression 8 57.16 Quite High
Neurodegenerative Disease 16 39.28 Quite Low
Nerve Degeneration 8 26.40 Quite Low
Gliosis 8 22.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate whether over-expression of A53T ?
Spec (investigate) Positive_regulation (investigate) of Spec (whether) Gene_expression (over) of A53T (A53T) associated with targeted disruption
1) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.82 Pain Relevance 0.18
These data suggest that the paralysis developed by A53T mice is not dependent on the developmental expression of A53T ?
Neg (not) Positive_regulation (dependent) of Gene_expression (expression) of A53T (A53T) associated with targeted disruption and paralysis
2) Confidence 0.30 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.73 Pain Relevance 0.29
The A53T transgenic mice displayed significant elevation of ?
Positive_regulation (transgenic mice) of Gene_expression (transgenic mice) of A53T (A53T) associated with targeted disruption
3) Confidence 0.28 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.42 Pain Relevance 0.22
The A53T transgenic mice developed an early onset rapidly progressed movement disability
Positive_regulation (transgenic mice) of Gene_expression (transgenic mice) of A53T (A53T) associated with targeted disruption
4) Confidence 0.28 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 1.80 Pain Relevance 0.19

General Comments

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