INT310908

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.38
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bcl2l11) mitochondrion (Bcl2l11) cytoplasm (Bcl2l11)
Anatomy Link Frequency
liver 1
hepatocytes 1
Bcl2l11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 63 91.04 High High
Inflammation 36 89.32 High High
cytokine 15 53.80 Quite High
ischemia 12 50.00 Quite Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 195 100.00 Very High Very High Very High
Death 36 96.44 Very High Very High Very High
INFLAMMATION 43 89.32 High High
Stress 59 64.04 Quite High
Adhesions 12 55.04 Quite High
Reperfusion Injury 8 50.00 Quite Low
Poisoning 27 40.16 Quite Low
Body Weight 85 5.00 Very Low Very Low Very Low
Hepatotoxicity 45 5.00 Very Low Very Low Very Low
Injury 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study also showed that taurine treatment prevented As-induced activation of Bim-EL in liver and hepatocytes.
Positive_regulation (activation) of Bim-EL in hepatocytes
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.51 Pain Relevance 0.10
These observations are in consistent with the data of other models where JNK-dependent Bim induction as well as phosphorylation with downstream activation of Bax-mediated apoptosis have been reported [39], [40].
Positive_regulation (induction) of Bim associated with apoptosis
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.45 Pain Relevance 0.21
The present study also showed that taurine treatment prevented As-induced activation of Bim-EL in liver and hepatocytes.
Positive_regulation (activation) of Bim-EL in liver
3) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.51 Pain Relevance 0.10
B in vitro and in vivo [33], which renders these cells more resistant to apoptosis by up-regulating the anti-apoptotic protein Bcl-xL and down-regulating the pro-apoptotic protein Bax [49].
Positive_regulation (up-regulating) of anti-apoptotic protein Bcl-xL associated with apoptosis
4) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.92 Pain Relevance 0.12

General Comments

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