INT310969

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.32
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (LPP) plasma membrane (LPP) nucleus (LPP)
biological_process (LPP) cytoplasm (LPP)
Anatomy Link Frequency
macrophages 1
immune cells 1
LPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 3 55.32 Quite High
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Yersinia Infection 222 99.92 Very High Very High Very High
Repression 3 99.80 Very High Very High Very High
Stress 27 93.20 High High
Mycobacterial Infection 3 92.24 High High
Bacterial Meningitis 3 88.52 High High
Shock 3 81.52 Quite High
Sprains And Strains 54 57.24 Quite High
Sepsis 3 56.00 Quite High
INFLAMMATION 3 54.92 Quite High
Infection 48 33.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results support a role for Lpp in Y. pestis adaptation to the host environment, possibly via transcriptional activation of htrA.


1.

Spec (possibly) Positive_regulation (role) of Lpp associated with yersinia infection
1) Confidence 0.30 Published 2010 Journal Comparative and Functional Genomics Section Abstract Doc Link PMC2873655 Disease Relevance 1.01 Pain Relevance 0.03
This suggests that Lpp-mediated intracellular survival of bacteria in host immune cells is mediated through the activation of the htrA gene transcription.
Positive_regulation (mediated) of Lpp in immune cells
2) Confidence 0.30 Published 2010 Journal Comparative and Functional Genomics Section Body Doc Link PMC2873655 Disease Relevance 0.68 Pain Relevance 0
lpp mutant in macrophages is mediated via repression of htrA gene transcription, based on our ability to restore survivability of ?
Positive_regulation (mediated) of lpp in macrophages associated with repression
3) Confidence 0.26 Published 2010 Journal Comparative and Functional Genomics Section Body Doc Link PMC2873655 Disease Relevance 0.63 Pain Relevance 0

General Comments

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