INT311

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.83
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tat) biosynthetic process (Tat) cellular amino acid metabolic process (Tat)
Anatomy Link Frequency
liver 3
Tat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 36 99.70 Very High Very High Very High
Opioid 6 99.00 Very High Very High Very High
tolerance 8 98.56 Very High Very High Very High
Angina 4 92.32 High High
antagonist 2 72.32 Quite High
narcan 2 71.44 Quite High
opiate 2 57.36 Quite High
Disease Link Frequency Relevance Heat
Disease 4 93.96 High High
Cv General 3 Under Development 4 92.32 High High
Diabetes Mellitus 2 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, such increase in TAT activity was invariably preceded by a prior decline in the enzyme level, as observed after 15 min of morphine treatment.
Positive_regulation (increase) of TAT associated with morphine
1) Confidence 0.67 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6143561 Disease Relevance 0.09 Pain Relevance 0.71
In this latter group of newborn rats narcotic administration causes TAT activity to return to levels as high as those of naive animals.
Positive_regulation (causes) of TAT
2) Confidence 0.67 Published 1978 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 28112 Disease Relevance 0 Pain Relevance 0.67
TAT induction is not evident in pregnant rats, given the narcotic, in which enzyme levels are already initially high.
Positive_regulation (induction) of TAT
3) Confidence 0.67 Published 1978 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 28112 Disease Relevance 0 Pain Relevance 0.52
On the other hand, morphine administration to the prole of naive rats results in an induction of liver TAT.
Positive_regulation (induction) of TAT in liver associated with morphine
4) Confidence 0.67 Published 1978 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 28112 Disease Relevance 0 Pain Relevance 0.64
Morphine treatment in normal intact rats caused a dose-dependent increase in hepatic tyrosine aminotransferase (TAT) activity, as demonstrable up to 2 hr of exposure to the opioid alkaloid.
Positive_regulation (increase) of TAT associated with opioid and morphine
5) Confidence 0.67 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6143561 Disease Relevance 0.08 Pain Relevance 0.62
Enzyme activity in fetal livers is much lower than that of adult animals: after maternal administration of morphine only a modest TAT increase is seen which is not, however, statistically significant.
Positive_regulation (increase) of TAT in livers associated with morphine
6) Confidence 0.45 Published 1978 Journal Arch. Toxicol. Suppl. Section Abstract Doc Link 28112 Disease Relevance 0 Pain Relevance 0.67
The present paper serves to elucidate the influence of oxypangam on the induction of the tyrosine aminotransferase, on the NAD content and on the activity of the ADPR transferase in the liver.
Positive_regulation (induction) of tyrosine aminotransferase in liver
7) Confidence 0.44 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 2881834 Disease Relevance 0.18 Pain Relevance 0.09
Influence of oxypangam upon the induction of tyrosine aminotransferase, the NAD content and the ADPR transferase activity in several organs of the rat.
Positive_regulation (induction) of tyrosine aminotransferase
8) Confidence 0.44 Published 1987 Journal Gen. Pharmacol. Section Title Doc Link 2881834 Disease Relevance 0.19 Pain Relevance 0.09
Our studies showed that in normal animals, increasing doses of oxypangam support the induction of tyrosine aminotransferase.
Positive_regulation (induction) of tyrosine aminotransferase
9) Confidence 0.44 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 2881834 Disease Relevance 0.16 Pain Relevance 0.08
Up to a concentration of 100 mg/kg oxypangam enhances also the induction of tyrosine aminotransferase by tryptophan.
Positive_regulation (induction) of tyrosine aminotransferase
10) Confidence 0.30 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 2881834 Disease Relevance 0.15 Pain Relevance 0.08

General Comments

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