INT311062

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELANE, HSF1) peptidase activity (ELANE) extracellular region (ELANE)
nucleolus (HSF1) nucleus (HSF1) protein complex (HSF1)
ELANE (Homo sapiens)
HSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 20 97.34 Very High Very High Very High
Shock 23 94.44 High High
Apoptosis 11 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A fundamental step in the activation of HSF1 is nuclear translocation.24,25 In the absence of stress, HSF1 is retained in the cytoplasm by inhibitory associations with Hsp70, Hsp90, and various cochaperones.(26) We demonstrated that HNE promotes the nuclear translocation of HSF1 using Western blot analysis, and showed the enhanced transcription of a luciferase reporter gene under the regulation of a conserved heat shock element.(27)
HNE Positive_regulation (promotes) of Localization (translocation) of HSF1 associated with stress and shock
1) Confidence 0.22 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.91 Pain Relevance 0

General Comments

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