INT311072

Context Info Confidence 0.22 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.53 Pain Relevance 0

unfolded protein binding (HSP90AA1) small molecule metabolic process (HSP90AA1) intracellular (HSP90AA1) response to stress (HSP90AA1) cytoplasm (HSP90AA1) cytosol (HSP90AA1)

Anatomy Link Frequency body 2 HSP90AA1 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 1 5.00 Inflammation 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Shock 23 95.88 Death 9 68.08 Apoptosis 11 64.52 Toxicity 4 43.92 Cancer 9 24.32 Stress 20 9.60 Pain 1 5.00 Nicotine Addiction 1 5.00 Disease 1 5.00 Aging 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our hypothesis that HNE modification of Hsp70 or Hsp90 leads to the release and activation of HSF1 is supported by a reasonable body of in vitro and in vivo results.19,27–29,40,41 However, it is also possible that modification of other cellular proteins leads to their unfolding, which attracts Hsp90 away from HSF1.

Positive_regulation (leads) of Localization (modification) of Hsp90 in body

1) Confidence 0.22 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.53 Pain Relevance 0

General Comments

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