INT311099

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP3) extracellular region (TIMP3) cytoplasm (TIMP3)
TIMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 79 100.00 Very High Very High Very High
metalloproteinase 4 100.00 Very High Very High Very High
Inflammation 3 88.16 High High
Pain 22 84.76 Quite High
imagery 1 35.12 Quite Low
Inflammatory mediators 1 27.16 Quite Low
interstitial cystitis 1 18.96 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 51 100.00 Very High Very High Very High
INFLAMMATION 5 88.16 High High
Pain 22 84.76 Quite High
Hydrarthrosis 3 84.40 Quite High
Osteoarthritis 7 77.20 Quite High
Knee Osteoarthritis 25 52.88 Quite High
Interstitial Cystitis 1 18.96 Low Low
Cv General 2 Under Development 1 10.24 Low Low
Thrombosis 1 8.52 Low Low
Disease 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show similar upregulation of two further anti-angiogenic protease inhibitors in OA, TIMP-3 and SLPI, with comparable expression patterns to TIMP-1.
Positive_regulation (upregulation) of Negative_regulation (inhibitors) of TIMP-3 associated with osteoarthritis
1) Confidence 0.22 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2877870 Disease Relevance 0.41 Pain Relevance 0.14
In recent years, it has been reported that pentosan interacts with a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4 and ADAMTS-5, and pentosan increased tissue inhibitor of metalloproteinase-3(TIMP-3)[17-19].
Positive_regulation (increased) of Negative_regulation (inhibitor) of metalloproteinase-3 associated with metalloproteinase
2) Confidence 0.12 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2873929 Disease Relevance 0.37 Pain Relevance 0.32

General Comments

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