INT31111

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Context Info
Confidence 0.38
First Reported 1987
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.52
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
lateral 4
neuronal 2
neurons 2
Car3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 12 100.00 Very High Very High Very High
Glutamate 12 100.00 Very High Very High Very High
opioid receptor 10 100.00 Very High Very High Very High
Pyramidal cell 5 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
tetrodotoxin 1 99.82 Very High Very High Very High
nMDA receptor antagonist 4 99.76 Very High Very High Very High
Potency 1 99.70 Very High Very High Very High
mu opioid receptor 4 99.28 Very High Very High Very High
carbamazepine 1 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 1 100.00 Very High Very High Very High
Death 1 100.00 Very High Very High Very High
Convulsion 5 91.64 High High
Motor Neuron Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the lesioned side, the potency of kainate in activating CA3 pyramidal neurons was reduced by 94% compared to the same neurons on the intact side.
Negative_regulation (reduced) of Positive_regulation (activating) of CA3 in neurons associated with pyramidal cell and potency
1) Confidence 0.38 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 2881802 Disease Relevance 0 Pain Relevance 0.56
Microinjection of Al (0.5 mol/L, 1 microliter) into CA3 could block the induction of LTP in CA3.
Negative_regulation (block) of Positive_regulation (induction) of CA3
2) Confidence 0.38 Published 1998 Journal J. Tongji Med. Univ. Section Abstract Doc Link 10806843 Disease Relevance 0 Pain Relevance 0.17
The induction of LTP at lateral perforant path-CA3 synapses, which is blocked by the opioid receptor antagonist naloxone, is also blocked by the selective mu opioid receptor antagonist Cys(2)-Tyr(3)-Orn(5)-Pen(7)-amide (CTOP), but not the selective delta opioid receptor antagonist naltrindole (NTI).
Negative_regulation (blocked) of Positive_regulation (induction) of CA3 in lateral associated with antagonist, mu opioid receptor, narcan and opioid receptor
3) Confidence 0.31 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826036 Disease Relevance 0 Pain Relevance 0.65
The induction of LTP at lateral perforant path-CA3 synapses, which is blocked by the opioid receptor antagonist naloxone, is also blocked by the selective mu opioid receptor antagonist Cys(2)-Tyr(3)-Orn(5)-Pen(7)-amide (CTOP), but not the selective delta opioid receptor antagonist naltrindole (NTI).
Negative_regulation (blocked) of Positive_regulation (induction) of CA3 in lateral associated with antagonist, mu opioid receptor, narcan and opioid receptor
4) Confidence 0.31 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826036 Disease Relevance 0 Pain Relevance 0.66
Tetrodotoxin largely prevented the increase of extracellular glutamate, the electroencephalographic epileptic discharges and the neuronal death in the CA1 and CA3 hippocampal regions.
Negative_regulation (prevented) of Positive_regulation (increase) of CA3 in neuronal associated with epilepsy, tetrodotoxin, glutamate and death
5) Confidence 0.30 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113304 Disease Relevance 0.52 Pain Relevance 0.87

General Comments

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