INT311143

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.74
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
plasma membrane (Cxcr1) intracellular (IL8) signal transducer activity (Cxcr1)
Anatomy Link Frequency
brain 2
IL8 (Homo sapiens)
Cxcr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 22 100.00 Very High Very High Very High
chemokine 8 100.00 Very High Very High Very High
ischemia 4 97.12 Very High Very High Very High
Neuronal excitability 2 86.00 High High
Hippocampus 34 83.52 Quite High
cytokine 2 75.64 Quite High
Pyramidal cell 48 51.72 Quite High
nMDA receptor 8 5.00 Very Low Very Low Very Low
Cannabinoid 8 5.00 Very Low Very Low Very Low
GABAergic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 100.00 Very High Very High Very High
Cv Unclassified Under Development 4 97.12 Very High Very High Very High
Injury 8 92.08 High High
Convulsion 36 84.56 Quite High
Status Epilepticus 114 64.32 Quite High
Apoptosis 16 63.04 Quite High
Neurodegenerative Disease 2 55.92 Quite High
Epilepsy 32 5.00 Very Low Very Low Very Low
Gliosis 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCR1 is a G-protein-coupled receptor activated by the pro-inflammatory chemokine, interleukin-8 (IL-8 or CXCL8), that is up-regulated under acute inflammatory conditions, e.g. after ischemia in the adult rabbit brain [66].
interleukin-8 Positive_regulation (activated) of CXCR1 in brain associated with chemokine, inflammation and ischemia
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.87 Pain Relevance 0.49
CXCR1 is a G-protein-coupled receptor activated by the pro-inflammatory chemokine, interleukin-8 (IL-8 or CXCL8), that is up-regulated under acute inflammatory conditions, e.g. after ischemia in the adult rabbit brain [66].
CXCL8 Positive_regulation (activated) of CXCR1 in brain associated with chemokine, inflammation and ischemia
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.87 Pain Relevance 0.49

General Comments

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