INT311146

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 0.39
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APRT) small molecule metabolic process (APRT) transferase activity, transferring glycosyl groups (APRT)
nucleolus (APRT) nucleus (APRT) cytoplasm (APRT)
APRT (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 17 87.72 High High
adenocard 17 82.52 Quite High
Disease Link Frequency Relevance Heat
Pneumoconiosis 34 78.08 Quite High
Toxicity 17 14.72 Low Low
Stress 51 9.32 Low Low
Aging 17 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the experiments where adenine was exposed to Fenton and pyrite-generated •OH, an increase in either the Fenton reagent, H2O2 or pyrite particle loadings (i.e., greater pyrite surface area) led to higher rates of adenine degradation.
Protein_catabolism (degradation) of adenine
1) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0.03
The aim of this study was to determine the effect of pyrite loading on the stability of adenine and to evaluate the adenine degradation products.
Protein_catabolism (degradation) of adenine
2) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0.04
To determine the susceptibility of adenine to •OH-induced degradation, several experiments were conducted.
Protein_catabolism (degradation) of adenine
3) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
The degradation of adenine in the presence of variable amounts of pyrite (1-100 g/L) was compared to adenine degradation in the presence of Fenton generated •OH.
Protein_catabolism (degradation) of adenine
4) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0.05 Pain Relevance 0
Experiments were also performed to determine the stability of adenine in the presence of pyrite; specifically, the role of pyrite-generated •OH in adenine degradation.
Spec (determine) Protein_catabolism (stability) of adenine
5) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
Although a decrease in light absorbance is indicative of a molecular structural change, spectrophotometry does not provide specific information on the adenine degradation products.
Protein_catabolism (degradation) of adenine
6) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
The degradation of adenine in the presence of variable amounts of pyrite (1-100 g/L) was compared to adenine degradation in the presence of Fenton generated •OH.
Protein_catabolism (degradation) of adenine
7) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0.05 Pain Relevance 0
SCF carried out the mass spectroscopy analyses of the degraded adenine and helped draft the manuscript sections on mass spectroscopy.
Spec (analyses) Protein_catabolism (degraded) of adenine
8) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0.09
The objective of this study was threefold: a) determine the effect of •OH concentration on the stability of the nucleobase adenine; b) determine if pyrite-generated •OH degrade adenine; and c) evaluate the adenine degradation products from reaction with pyrite.
Protein_catabolism (degradation) of adenine
9) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0.08 Pain Relevance 0
Mass spectroscopy of the degraded adenine
Protein_catabolism (degraded) of adenine
10) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
The addition of catalase or ethanol stabilizes the adenine indicating the putative mechanistic roles of H2O2 and •OH in degrading the adenine.
Protein_catabolism (degrading) of adenine
11) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
When the loading of pyrite particles in the presence of adenine is increased, the adenine degradation rate also increases (Figure 3).
Protein_catabolism (degradation) of adenine
12) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
In order to evaluate •OH-induced degradation of adenine, several experiments were performed exposing adenine solutions to various reactants and pyrite suspensions.
Protein_catabolism (degradation) of adenine
13) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0.07 Pain Relevance 0
The aim of this study was to determine the effect of pyrite loading on the stability of adenine and to evaluate the adenine degradation products.
Protein_catabolism (stability) of adenine
14) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0.04
Experiments were also performed to determine the stability of adenine in the presence of pyrite; specifically, the role of pyrite-generated •OH in adenine degradation.
Protein_catabolism (degradation) of adenine
15) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0 Pain Relevance 0
The objective of this study was threefold: a) determine the effect of •OH concentration on the stability of the nucleobase adenine; b) determine if pyrite-generated •OH degrade adenine; and c) evaluate the adenine degradation products from reaction with pyrite.
Protein_catabolism (degrade) of adenine
16) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0.08 Pain Relevance 0
Adenine degradation experiments
Protein_catabolism (degradation) of Adenine
17) Confidence 0.01 Published 2010 Journal Geochem Trans Section Body Doc Link PMC2873965 Disease Relevance 0.06 Pain Relevance 0

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