INT31116

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 4
Speculated 9
Reported most in Abstract
Documents 192
Total Number 201
Disease Relevance 78.21
Pain Relevance 57.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
livers 9
neurons 7
oocytes 4
brain 4
spinal cord 3
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 704 100.00 Very High Very High Very High
Morphine 401 100.00 Very High Very High Very High
Paracetamol 62 99.84 Very High Very High Very High
Clonidine 18 99.70 Very High Very High Very High
antagonist 183 99.54 Very High Very High Very High
Spinal cord 159 99.52 Very High Very High Very High
Serotonin 189 99.38 Very High Very High Very High
Lamotrigine 10 99.32 Very High Very High Very High
Sciatic nerve 11 99.28 Very High Very High Very High
Dopamine 439 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 2837 100.00 Very High Very High Very High
Death 659 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 25 100.00 Very High Very High Very High
Hypoxia 13 100.00 Very High Very High Very High
Coronary Artery Disease 29 99.76 Very High Very High Very High
Cancer 2288 99.62 Very High Very High Very High
Necrosis 113 99.60 Very High Very High Very High
Frailty 224 99.40 Very High Very High Very High
Targeted Disruption 247 99.36 Very High Very High Very High
Disease 264 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 3-4 mm rostral or caudal to the injury, >90% of all neurons, astrocytes and oligodendrocytes expressed active caspase-3 in both wild-type and knockout mice.
Gene_expression (expressed) of caspase-3 in oligodendrocytes associated with targeted disruption and injury
1) Confidence 0.78 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 0.94 Pain Relevance 0.31
In contrast, while caspase-3 expression in neurons also declined with further distance from the injury, there was no effect of genotype.
Gene_expression (expression) of caspase-3 in neurons associated with injury
2) Confidence 0.78 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 1.03 Pain Relevance 0.39
Expression of cleaved caspase-3 was not significantly different from that of untreated tumours, except at the time point of 2 h where it was maximal (58%).
Gene_expression (Expression) of caspase-3 associated with cancer
3) Confidence 0.75 Published 2005 Journal Cryobiology Section Abstract Doc Link 15963488 Disease Relevance 1.08 Pain Relevance 0.18
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Gene_expression (expression) of caspase-3
4) Confidence 0.75 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1alpha (HIF-1alpha) expression in liver tissue.
Gene_expression (expression) of caspase-3 in liver associated with necrosis and hypoxia
5) Confidence 0.75 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.60 Pain Relevance 0.62
Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.
Gene_expression (expression) of caspase-3 associated with qutenza, cancer and apoptosis
6) Confidence 0.75 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.77 Pain Relevance 0.87
At the end of the experiment plasma CT was measured by radioimmunoassay, the number of proliferating cells in tumor tissues was detected by Ki67 immunocytochemistry and apoptotic nuclei by caspase 3 ad Bcl-2 expression and terminal-deoxynucleotidyl-transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) method.
Gene_expression (expression) of caspase 3 in plasma
7) Confidence 0.75 Published 2009 Journal Thyroid Section Body Doc Link 19281427 Disease Relevance 0.15 Pain Relevance 0
EA also showed an regulatory effect on the increased the expression of CPP32 and decreased the expression of Bcl-2 by morphine.
Gene_expression (expression) of CPP32 associated with acupuncture and morphine
8) Confidence 0.73 Published 2000 Journal Acupunct Electrother Res Section Abstract Doc Link 10830972 Disease Relevance 0.31 Pain Relevance 1.06
N(2)O did not induce CPP but impaired the acquisition of morphine-induced CPP and blocked the expression of cocaine- and morphine-induced CPP.
Gene_expression (expression) of CPP associated with cocaine and morphine
9) Confidence 0.68 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.38 Pain Relevance 0.83
Administration of Ro 64-6198 (0.3 or 1 mg/kg, i.p.) on the test day alone, in a separate group of animals, failed to block the expression of morphine CPP.
Gene_expression (expression) of CPP associated with morphine
10) Confidence 0.68 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15919100 Disease Relevance 0.06 Pain Relevance 1.06
Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.
Gene_expression (expression) of CPP associated with morphine
11) Confidence 0.68 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16182480 Disease Relevance 0 Pain Relevance 0.66
Another group of mice was conditioned to morphine to develop CPP, and then exposed to the CPP chambers in the absence of drug once a day for 30 min to extinguish the CPP.
Gene_expression (exposed) of CPP associated with morphine
12) Confidence 0.67 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15919100 Disease Relevance 0.06 Pain Relevance 1.10
MPEP at 30, but not 10 mg/kg significantly inhibited the acquisition as well as expression of morphine-induced CPP, but it neither produced place preference or aversion, nor affected locomotor activity of mice.
Gene_expression (expression) of CPP associated with eae and morphine
13) Confidence 0.67 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527470 Disease Relevance 0 Pain Relevance 0.60
Results of these experiments indicate that increased blood DNA levels occurred with all three agents and were highest with anti-Fas and CCl(4); caspase 3 levels were much higher with anti-Fas than the other agents.
Gene_expression (levels) of caspase 3 in blood
14) Confidence 0.65 Published 2008 Journal Biomarkers Section Abstract Doc Link 18270870 Disease Relevance 1.09 Pain Relevance 0.25
A 4-fold induction of keratinocyte apoptosis was observed in knockouts relative to WT animals, as documented by terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling and caspase-3 staining.
Gene_expression (staining) of caspase-3 in keratinocyte associated with apoptosis
15) Confidence 0.65 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15313895 Disease Relevance 0.87 Pain Relevance 0.07
In contrast to the report by Cho et al. [33], we observed that Thy1high cells are mainly contained within the CD24alow/Sca1high subset (Figure 8A); however a small fraction of cells co-expressed Thy1 and CD24a (Figure 8B).
Gene_expression (expressed) of Sca1
16) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.09 Pain Relevance 0
In contrast, 5HT1A activation (which occurs preferentially after menopause) decreases apoptotic signaling via caspase-3 suppression [38].
Gene_expression (suppression) of caspase-3 associated with endometriosis (extended) and apoptosis
17) Confidence 0.65 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.80 Pain Relevance 0.13
By immunofluorescence or in situ fluorogenic substrate assay, caspase-1 and caspase-3 expression were detected in neuronal and non-neuronal cells following spinal cord injury.
Gene_expression (expression) of caspase-3 in neuronal associated with spinal cord
18) Confidence 0.62 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938439 Disease Relevance 1.00 Pain Relevance 0.43
Mice were exposed to N(2)O during the conditioning phase (acquisition of CPP) or during postconditioning phase (expression of CPP).
Gene_expression (expression) of CPP
19) Confidence 0.60 Published 2007 Journal Neuroscience Section Abstract Doc Link 17905521 Disease Relevance 0.25 Pain Relevance 0.54
behavior in mice, and thus, the CPP
Gene_expression (behavior) of CPP
20) Confidence 0.59 Published 2003 Journal Neural Plasticity Section Abstract Doc Link PMC2565430 Disease Relevance 0.06 Pain Relevance 0.64

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