INT31117

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Context Info
Confidence 0.23
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 5.27
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
neuronal 1
neurons 1
labyrinth 1
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 3 98.76 Very High Very High Very High
Inflammation 36 96.96 Very High Very High Very High
antagonist 19 96.84 Very High Very High Very High
Glutamate 7 94.28 High High
cva 8 90.84 High High
local anesthetic 1 85.48 High High
Inflammatory response 10 84.72 Quite High
cytokine 23 82.52 Quite High
Hippocampus 48 64.52 Quite High
excitatory amino acid 1 58.28 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 316 99.10 Very High Very High Very High
INFLAMMATION 51 96.96 Very High Very High Very High
Cerebral Malaria 110 95.72 Very High Very High Very High
Disease 45 91.84 High High
Cv General 3 Under Development 8 90.84 High High
Osteoporosis 17 90.64 High High
Stress 146 86.36 High High
Lymphoproliferative Disease 1 84.00 Quite High
Cancer 6 83.72 Quite High
Convulsion 15 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CPP (10 muM) failed to interact with any of 21 other putative neurotransmitter receptors including alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding (quisqualate-type receptor) and [3H]kainate binding (kainate-type receptor).
CPP Binding (interact) of associated with neurotransmitter
1) Confidence 0.23 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2882014 Disease Relevance 0.23 Pain Relevance 0.48
Casein phosphopeptide (CPP), recognized as a specified food for health, is also included.
CPP Binding (recognized) of
2) Confidence 0.15 Published 2009 Journal Nutr J Section Body Doc Link PMC2711110 Disease Relevance 0.49 Pain Relevance 0
The endogenous active caspase-3 bound to
caspase-3 Binding (bound) of
3) Confidence 0.15 Published 2009 Journal PPAR Research Section Body Doc Link PMC2651001 Disease Relevance 0.13 Pain Relevance 0
We find that for CC1, for CC2, and for CC3.
CC3 Binding (find) of
4) Confidence 0.13 Published 2010 Journal Health Care Manag Sci Section Body Doc Link PMC2886895 Disease Relevance 0 Pain Relevance 0
In association with these changes, a dramatic inhibition of activated caspase-3 was observed.
caspase-3 Binding (association) of
5) Confidence 0.12 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.76 Pain Relevance 0.08
Cur prevents caspase-3 activation and inhibits COX-2 expression
caspase-3 Binding (activation) of
6) Confidence 0.12 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
Rabbit monoclonal antibody against activated caspase-3 (Cell Signaling) was diluted 1:1,000 and permitted to bind overnight at 4°C.
caspase-3 Binding (bind) of
7) Confidence 0.11 Published 2009 Journal Malar J Section Body Doc Link PMC2651188 Disease Relevance 0 Pain Relevance 0
It has previously been shown that immunoreactivity for cleaved (i.e. activated) caspase 3 is increased in brains of mice with ECM [26], without a topographical association with TUNEL+ neurons.
caspase 3 Binding (association) of in neurons
8) Confidence 0.09 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.82 Pain Relevance 0.12
Three-way ANOVA revealed significant pretreatment×treatment×pairing interaction for CPP (F (4,84)?
CPP Binding (interaction) of
9) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516177 Disease Relevance 0.42 Pain Relevance 0
There was a strong temporal and spatial association between TUNEL staining and immunoreactivity for HNE (Fig. 4a) and active caspase-3 (Fig. 4b).
caspase-3 Binding (association) of
10) Confidence 0.08 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.48 Pain Relevance 0
The activity of caspase-3 in cell extracts was expressed as pmol/min

?

caspase-3 Binding (activity) of
11) Confidence 0.07 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276911 Disease Relevance 0 Pain Relevance 0
The labyrinth showed low immunoreactivity for active-caspase 3 until E18 (Fig. 4b), but thereafter it increased in intensity until E19.
caspase 3 Binding (immunoreactivity) of in labyrinth
12) Confidence 0.07 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.39 Pain Relevance 0
Similar to previous reports, we found that injections of CPP given prior to training were more effective at blocking learning in context A than context B (significant context x drug interaction F (1, 14) ?
CPP Binding (injections) of
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.07 Pain Relevance 0.07
Brains of terminally ill infected mice showed apoptosis of neuronal cells, as detected by TUNEL and caspase 3 antibody binding [28].
caspase 3 Binding (binding) of in neuronal associated with apoptosis
14) Confidence 0.04 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.50 Pain Relevance 0.10
The mean expression change of each gene was summarized for all time points together for correlation with CPP and for single time points for correlation with locomotor activation.


CPP Binding (correlation) of
15) Confidence 0.03 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.08

General Comments

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