INT311173

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Gba) carbohydrate metabolic process (Gba) lipid metabolic process (Gba)
lysosome (Gba)
Anatomy Link Frequency
liver 1
storage cells 1
Gba (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Antihistamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 98.24 Very High Very High Very High
Gauchers Disease 32 50.00 Quite Low
Death 10 5.00 Very Low Very Low Very Low
Anaphylaxis 6 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Fibrosarcoma 4 5.00 Very Low Very Low Very Low
Anaemia 2 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Thrombocytopenia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice were sacrificed one week after the last injection, and sera and organs were collected for serologic studies, GCase activities, GC levels, and quantification of storage cells.
Regulation (collected) of GCase in storage cells
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0
These results suggest that, although minor, the more rapid clearance of the GCases from the liver in the less involved mice could impact the continued improvement in patients, e.g., as their overall disease, particularly the liver involvement, is reversed, the length of time that their organs experience a therapeutic level of the GCases could be shortened and the rate of reversal could slow [8], [18].
Regulation (experience) of GCase in liver associated with disease
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.21 Pain Relevance 0

General Comments

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