INT311174

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 2.42
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Sh2d1b2)
Anatomy Link Frequency
urine 3
tubules 2
dorsal root ganglia 1
Sh2d1b2 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 20 98.48 Very High Very High Very High
Pain 1 97.92 Very High Very High Very High
Neuropathic pain 20 79.28 Quite High
peripheral neuropathy 30 64.40 Quite High
hypoalgesia 10 61.96 Quite High
Spinal cord 20 5.00 Very Low Very Low Very Low
isoflurane 12 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
analgesia 10 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 1 99.28 Very High Very High Very High
Gauchers Disease 86 99.16 Very High Very High Very High
Pain 1 97.92 Very High Very High Very High
Thrombocytopenia 1 95.64 Very High Very High Very High
Anaemia 1 94.80 High High
Targeted Disruption 20 90.08 High High
Fabry Disease 180 90.04 High High
Disease 118 87.68 High High
Neuropathic Pain 30 79.28 Quite High
Peripheral Neuropathy 30 64.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combined ERT and SRT is most effective at reducing uromodulin levels in the urine of Fabry-Rag mice
ERT Binding (Combined) of in urine
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Combined ERT and SRT is most effective at reducing GL-3 levels in tissues of the Fabry-Rag mouse
ERT Binding (Combined) of
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.06 Pain Relevance 0.06
Although both ERT and SRT monotherapies decreased DRG vacuolation relative to that seen in untreated mice, the combination of ERT and SRT produced the largest beneficial effect, decreasing vacuolation by ?
ERT Binding (combination) of
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.05 Pain Relevance 0.03
This observation suggests that a combination of ERT and SRT may benefit those Fabry patients whose renal function continues to decline even when on ERT [26].
ERT Binding (combination) of
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
In any case, excreted uromodulin may be reflecting GL-3 buildup in the distal tubules, and these changes can be normalized most effectively in the mouse model by a combined ERT plus SRT approach.


ERT Binding (combined) of in tubules
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Combined ERT and SRT is most effective at reducing the number of vacuolated neurons in the dorsal root ganglia of Fabry-Rag mice
ERT Binding (Combined) of in dorsal root ganglia
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.16 Pain Relevance 0.13
In any case, excreted uromodulin may be reflecting GL-3 buildup in the distal tubules, and these changes can be normalized most effectively in the mouse model by a combined ERT plus SRT approach.


ERT Binding (normalized) of in tubules
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
As an inhibitor of glucosylceramide synthase, eliglustat tartrate has been shown to be effective as both a monotherapy and in combination with ERT in a mouse model of Gaucher disease [18], [19].
ERT Binding (combination) of associated with gauchers disease
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 1.13 Pain Relevance 0.06
Taking into account the effects of combination ERT and SRT on urine volume (data not shown; see Figure 2), total uromodulin amounts excreted over a 24 h period were most effectively reduced by the combined ERT and SRT approaches (?
ERT Binding (combination) of in urine
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Taking into account the effects of combination ERT and SRT on urine volume (data not shown; see Figure 2), total uromodulin amounts excreted over a 24 h period were most effectively reduced by the combined ERT and SRT approaches (?
ERT Binding (combined) of in urine
10) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
ERT also can restore normal growth patterns in the ?
ERT Binding (restore) of
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 1.02 Pain Relevance 0.10

General Comments

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