INT311176

Context Info Confidence 0.17 First Reported 2010 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 0.50 Pain Relevance 0

extracellular region (Crim1)

Anatomy Link Frequency spleen 2 Crim1 (Mus musculus)

Pain Link Frequency Relevance Heat isoflurane 12 36.60 corticosteroid 6 5.00 Inflammatory response 6 5.00 Pain 6 5.00 Antihistamine 6 5.00

Disease Link Frequency Relevance Heat Stroke 6 82.24 Body Weight 12 72.04 Stupor 6 60.88 Gauchers Disease 96 50.00 Disease 48 5.00 Death 30 5.00 Anaphylaxis 18 5.00 Fibrosarcoma 12 5.00 Anaemia 6 5.00 Heart Rate Under Development 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunoblots, CRIM, and CRIM-SA

Gene_expression (Immunoblots) of CRIM

1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.14 Pain Relevance 0

Immunoblots, CRIM, and CRIM-SA

Gene_expression (Immunoblots) of CRIM

2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.14 Pain Relevance 0

When expressed as CRIM-SA, the decreasing values indicate losses of intrinsic catalytic activity during prolonged exposure to serum, so that by 20 min the intact enzyme remaining in serum has <10% of its original catalytic value.

Gene_expression (expressed) of CRIM

3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.07 Pain Relevance 0

CRIM-SA was based on the amount (ng) of intact GCase (Mr?

Gene_expression (based) of CRIM

4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0.14 Pain Relevance 0

The CRIM-SA of Vela or Imig in spleen was stable up to 4 h; by 18–42 h CRIM was not reliably detected.

Neg (not) Gene_expression (detected) of CRIM in spleen

5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0

The CRIM-SA of Vela or Imig in spleen was stable up to 4 h; by 18–42 h CRIM was not reliably detected.

Neg (not) Gene_expression (detected) of CRIM in spleen

6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873993 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.