INT31118

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Context Info
Confidence 0.73
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 11.55
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
poly 2
cleavage 2
hearts 2
macrophages 1
Plasma 1
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 12 99.92 Very High Very High Very High
Inflammation 54 93.76 High High
Paracetamol 3 93.40 High High
antagonist 5 89.08 High High
cytokine 23 88.64 High High
Glutamate 4 87.52 High High
excitatory amino acid 1 85.60 High High
local anesthetic 1 78.40 Quite High
chemokine 22 70.72 Quite High
imagery 16 61.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 366 99.96 Very High Very High Very High
Injury 69 99.56 Very High Very High Very High
INFLAMMATION 68 99.26 Very High Very High Very High
Death 78 99.16 Very High Very High Very High
Cognitive Disorder 4 99.04 Very High Very High Very High
Diabetes Mellitus 356 98.72 Very High Very High Very High
Targeted Disruption 112 98.02 Very High Very High Very High
Cancer 83 97.80 Very High Very High Very High
Colorectal Cancer 1 96.28 Very High Very High Very High
Myeloid Leukemia 50 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proapoptotic effect of rolipram was associated with decreased levels of the prosurvival protein Mcl-1 and increased caspase-3 cleavage.
Localization (cleavage) of caspase-3 in cleavage
1) Confidence 0.73 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.76 Pain Relevance 0.31
Plasma DNA was measured fluorometrically by the dye PicoGreen while lactate dehydrogenase (LDH) and caspase 3, other molecules released with cell injury or death, were measured by enzymatic assays.
Localization (released) of caspase 3 in Plasma associated with injury and death
2) Confidence 0.68 Published 2008 Journal Biomarkers Section Abstract Doc Link 18270870 Disease Relevance 1.07 Pain Relevance 0.25
CONCLUSION: We show for the first time that caspase-1 and caspase-3 activities localize specifically within neurons after experimental brain trauma.
Localization (localize) of caspase-3 in brain
3) Confidence 0.60 Published 2001 Journal Neurosurgery Section Body Doc Link 11383749 Disease Relevance 0.10 Pain Relevance 0
The antagonism by CPP of NMDA-evoked [3H]ACh release was competitive, with a pA2 of 5.66 for CPP, compared with a pA2 value of 5.22 for 2-amino-7-phosphonoheptanoate.
Localization (release) of CPP
4) Confidence 0.45 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2882014 Disease Relevance 0 Pain Relevance 0.42
Membranes were probed with the following antibodies: HSP25 (Stressgen, Victoria, BC, Canada), total p38MAPK, phospho-p38MAPK and cleaved caspase-3 (Cell Signaling Technology, Inc.
Localization (cleaved) of caspase-3
5) Confidence 0.24 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
-actin, cat. no. 241014, caspase 3, cat. no. 241124, no. 241054, caspase 1, cat. no. 241151, TNF, cat. no. 241034, IFN-?
Localization (cat.) of caspase 3
6) Confidence 0.21 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0 Pain Relevance 0
1's anti-apoptotic effect on ECs, we examined cleavage of caspase 3, a key step in the apoptotic cascade, and the BCl-2 family of proteins, which also plays a role in apoptosis.
Localization (cleavage) of caspase 3 in cleavage associated with apoptosis
7) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.92 Pain Relevance 0
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Localization (cleavage) of caspase-3 in poly associated with cancer and apoptosis
8) Confidence 0.17 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.09 Pain Relevance 0.06
Furthermore, key markers of apoptosis, caspase-3 activity and cytochrome c release, were reduced in the hearts of diabetic RAGE-modified mice compared with wild-type diabetic littermates in I/R.
Localization (release) of caspase-3 in hearts associated with diabetes mellitus and apoptosis
9) Confidence 0.16 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453611 Disease Relevance 1.64 Pain Relevance 0.03
Dual-fluorescence TUNEL assay & Active Caspase-3, and HNE co-localisation
Localization (localisation) of Caspase-3
10) Confidence 0.15 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.46 Pain Relevance 0
We observed that in diabetic RAGE KO, Tg DN PPET RAGE, and Tg DN MSR RAGE mice hearts, protection from injury due to I/R was also associated with reductions in caspase-3 activation and cytochrome c release.
Localization (release) of caspase-3 in hearts associated with targeted disruption, diabetes mellitus and injury
11) Confidence 0.14 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.20 Pain Relevance 0
SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release.
Localization (release) of caspase-3 associated with inflammation, cinod and apoptosis
12) Confidence 0.12 Published 2008 Journal Cancer Res. Section Title Doc Link 18172320 Disease Relevance 0.95 Pain Relevance 0.93
Both eyeblink classical conditioning (EBCC) and object recognition memory (ORM) induced an increase in histone H3 acetylation (Ac-H3).
Localization (acetylation) of Ac-H3 associated with cognitive disorder
13) Confidence 0.12 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18638560 Disease Relevance 0.26 Pain Relevance 0.05
The existence of high levels of free iron and H2O2 inside mitochondria favours the generation of highly toxic ┬░OH, oxidation of mitochondrial lipids, release of cytochrome c into the cytosol, and activation of caspase 9/caspase 3 to execute hepatocyte apoptosis.
Localization (release) of caspase 3 in hepatocyte associated with apoptosis
14) Confidence 0.09 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.17 Pain Relevance 0
Antibodies specific for Bax, Bak, Mcl-1, Bim, phospho-Bad, total Bad, Puma, Bcl-2, Bcl-XL, cleaved poly-ADP ribose polymerase (PARP), cleaved caspase-3, cleaved caspase-9, cleaved caspase-8, and cleaved caspase-7 were from (Cell Signaling, Danvers, MA, USA).
Localization (cleaved) of caspase-3 in poly
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.62 Pain Relevance 0
Our results show that non-covalent attachment of cyt c to PS-coated SWCNTs, and subsequent release of cyt c inside macrophages using an endosome-disrupting agent, effectively activated caspase-3 in these cells, indicative of activation of apoptosis.
Localization (release) of caspase-3 in macrophages associated with apoptosis
16) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2634966 Disease Relevance 0.31 Pain Relevance 0.25
Localization and Intensity of Ac-H3
Localization (Localization) of Ac-H3
17) Confidence 0.03 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0

General Comments

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