INT3112

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2008
Negated 3
Speculated 2
Reported most in Abstract
Documents 39
Total Number 41
Disease Relevance 4.73
Pain Relevance 13.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
brain 8
liver 4
lung 4
heart 4
stomach 2
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 59 100.00 Very High Very High Very High
Morphine 44 100.00 Very High Very High Very High
Opioid 29 100.00 Very High Very High Very High
opioid receptor 16 100.00 Very High Very High Very High
opiate 25 99.72 Very High Very High Very High
Catecholamine 2 99.48 Very High Very High Very High
Central nervous system 5 99.44 Very High Very High Very High
Paracetamol 10 99.08 Very High Very High Very High
narcan 26 97.80 Very High Very High Very High
Intracerebroventricular 4 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Liver Failure 3 100.00 Very High Very High Very High
Necrosis 9 99.04 Very High Very High Very High
Vibrio Infection 6 98.70 Very High Very High Very High
Duodenal Ulcer 4 97.72 Very High Very High Very High
Apoptosis 2 97.64 Very High Very High Very High
Injury 10 96.64 Very High Very High Very High
Peptic Ulcer 5 95.92 Very High Very High Very High
Breast Cancer 1 95.46 Very High Very High Very High
Coronary Heart Disease 1 91.08 High High
Pain 1 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methadone was administered daily to pregnant or nursing rats, or directly to neonates, and the effects on brain and heart weights and ornithine decarboxylase (ODC) activities were determined during postnatal development.
Regulation (effects) of ODC in heart associated with methadone
1) Confidence 0.62 Published 1976 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 978475 Disease Relevance 0 Pain Relevance 0.41
Methadone was administered daily to pregnant or nursing rats, or directly to neonates, and the effects on brain and heart weights and ornithine decarboxylase (ODC) activities were determined during postnatal development.
Regulation (effects) of ornithine decarboxylase in heart associated with methadone
2) Confidence 0.62 Published 1976 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 978475 Disease Relevance 0 Pain Relevance 0.40
The effect of asparagine was totally blocked by inhibition of either protein or RNA synthesis, suggesting that the inducing amino acids increase ODC activity by stimulating the transcription of genes directly or indirectly regulating ODC activity.
Regulation (regulating) of ODC
3) Confidence 0.62 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.33
Several factors involved in the regulation of ornithine decarboxylase (ODC) activity in adult rat brain tissue have been identified by using the in vitro hippocampal slice preparation.
Regulation (regulation) of ODC in brain
4) Confidence 0.62 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0
Several factors involved in the regulation of ornithine decarboxylase (ODC) activity in adult rat brain tissue have been identified by using the in vitro hippocampal slice preparation.
Regulation (regulation) of ornithine decarboxylase in brain
5) Confidence 0.62 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0
Morphine per se neither modified whole brain ODC activity nor significantly affected the ODC inhibitory effect of DFMO.
Neg (nor) Regulation (affected) of ODC in brain associated with morphine
6) Confidence 0.62 Published 1989 Journal Life Sci. Section Abstract Doc Link 2494400 Disease Relevance 0.09 Pain Relevance 1.04
Because changes in ODC levels during early postnatal life are associated with perturbations in tissue growth and/or function, the data suggest that CNS BE may influence lung maturation through an indirect action that may involve glucocorticoids.
Regulation (changes) of ODC in lung
7) Confidence 0.62 Published 1991 Journal Pediatr. Res. Section Abstract Doc Link 2014156 Disease Relevance 0 Pain Relevance 0.14
The results from these studies demonstrate that the pituitary is not the conduit by which either MS or centrally-administered BE regulates liver ODC activity.
Regulation (regulates) of ODC in liver
8) Confidence 0.62 Published 1994 Journal Life Sci. Section Abstract Doc Link 8107512 Disease Relevance 0 Pain Relevance 0.21
The experiments with enterotoxins suggest that cAMP is the intracellular second messenger controlling intestinal ODC activity.
Regulation (controlling) of ODC
9) Confidence 0.61 Published 1993 Journal Acta Physiol. Scand. Section Abstract Doc Link 8128898 Disease Relevance 0.23 Pain Relevance 0.08
Effect of hepatic failure toxins on liver thymidine kinase activity and ornithine decarboxylase activity after massive necrosis with acetaminophen in the rat.
Regulation (Effect) of ornithine decarboxylase in liver associated with liver failure, necrosis and paracetamol
10) Confidence 0.60 Published 1985 Journal J. Lab. Clin. Med. Section Title Doc Link 4056569 Disease Relevance 0.57 Pain Relevance 0.32
Effects of methadone on ornithine decarboxylase and cyclic nucleotide phosphohydrolase in neuronal and glial cell cultures.
Regulation (Effects) of ornithine decarboxylase in neuronal associated with methadone
11) Confidence 0.50 Published 1982 Journal J. Neurosci. Res. Section Title Doc Link 6284952 Disease Relevance 0 Pain Relevance 0.33
However the drug did not affect ODC induced by other stimuli.
Neg (not) Regulation (affect) of ODC
12) Confidence 0.50 Published 1998 Journal Mol. Cell. Biochem. Section Abstract Doc Link 9746211 Disease Relevance 0.07 Pain Relevance 0.38
We compared the responses of rat stomach ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) to food intake, oral treatment with antisecretagogues, NaHCO3, and hypertonic NaCl, antrectomy, intravenous infusion of gastrin-17, the selective cholecystokinin (CCK)-B/gastrin receptor antagonist L-365,260, and the somatostatin analogue RC-160.
Regulation (responses) of ODC in stomach associated with antagonist, somatostatin and cholecystokinin
13) Confidence 0.45 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638714 Disease Relevance 0 Pain Relevance 0.14
We compared the responses of rat stomach ornithine decarboxylase (ODC) and histidine decarboxylase (HDC) to food intake, oral treatment with antisecretagogues, NaHCO3, and hypertonic NaCl, antrectomy, intravenous infusion of gastrin-17, the selective cholecystokinin (CCK)-B/gastrin receptor antagonist L-365,260, and the somatostatin analogue RC-160.
Regulation (responses) of ornithine decarboxylase in stomach associated with antagonist, somatostatin and cholecystokinin
14) Confidence 0.45 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638714 Disease Relevance 0 Pain Relevance 0.14
This study examined whether the developmental deficits usually observed in infants born to opiate addicted mothers could involve effects on ornithine decarboxylase, a growth-controlling enzyme.
Regulation (effects) of ornithine decarboxylase associated with opiate
15) Confidence 0.41 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.39
This does not imply that the opiate is unable to affect ornithine decarboxylase when applied systemically.
Neg (unable) Regulation (affect) of ornithine decarboxylase associated with opiate
16) Confidence 0.41 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.85
Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats.
Regulation (Responses) of ornithine decarboxylase in sympathetic associated with catecholamine and methadone
17) Confidence 0.39 Published 1978 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 633081 Disease Relevance 0.09 Pain Relevance 0.68
Regulators of these processes such as ODC, Bcl-2, VEGF and EGF receptor are likely to be involved in the healing action of L. rhamnosus GG for gastric ulcer.
Regulation (Regulators) of ODC associated with peptic ulcer
18) Confidence 0.38 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.07 Pain Relevance 0.05
Although our acute dataset predominantly showed up-regulation for these genes, chronic profiles indicated biphasic responses, especially for ODC and CEBP-beta.
Regulation (regulation) of ODC
19) Confidence 0.31 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.11
This study examined whether the developmental deficits usually observed in infants born to opiate addicted mothers could involve effects on ornithine decarboxylase, a growth-controlling enzyme.
Regulation (effects) of ornithine decarboxylase associated with opiate
20) Confidence 0.30 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.39

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