INT31122

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.44
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc25a1) mitochondrion (Slc25a1)
Anatomy Link Frequency
forearm 1
HeLa 1
MVD 1
Slc25a1 (Mus musculus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 134 99.68 Very High Very High Very High
antagonist 16 98.88 Very High Very High Very High
agonist 18 98.76 Very High Very High Very High
intrathecal 4 98.76 Very High Very High Very High
Enkephalin 10 97.88 Very High Very High Very High
analgesia 4 94.00 High High
narcan 6 92.88 High High
Somatostatin 10 87.44 High High
Opioid 6 86.84 High High
Analgesic 8 84.84 Quite High
Disease Link Frequency Relevance Heat
Carpal Tunnel Syndrome 160 99.68 Very High Very High Very High
Cervical Cancer 3 72.12 Quite High
General Immunology 3 69.64 Quite High
Fibrosarcoma 6 66.80 Quite High
Reperfusion Injury 12 37.28 Quite Low
Cv Unclassified Under Development 5 32.60 Quite Low
Atherosclerotic Plaque 6 27.92 Quite Low
Obesity 6 24.92 Low Low
Cancer 6 23.64 Low Low
Myocardial Infarction 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is unclear how the ability of CTP to interact with these cellular components in vitro facilitates transduction of cardiac specific tissue in vivo.
CTP Binding (interact) of
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923200 Disease Relevance 0 Pain Relevance 0
As shown in figure 2, significant internalization of CTP-6-CF was observed in H9C2 cells compared to relatively minor internalization by 3T3, MCA-205 and HeLa cells at high concentrations, with no appreciable uptake by HK-2 cells.
CTP-6-CF Binding (internalization) of in HeLa
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923200 Disease Relevance 0 Pain Relevance 0
Twenty-four hours later, cells were treated with increasing concentrations of CTP-NBD and 30-minutes later challenged with murine TNF-?
CTP-NBD Binding (concentrations) of
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923200 Disease Relevance 0.27 Pain Relevance 0.04
In aggregate, these studies suggest that CTS development is associated with elevated CTP.
CTP Binding (associated) of associated with carpal tunnel syndrome
4) Confidence 0.28 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.74 Pain Relevance 0.47
Several studies have measured the CTP profile associated with different wrist angles, finger flexion and forearm position [39,40,42,43].
CTP Binding (associated) of in forearm
5) Confidence 0.28 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2569035 Disease Relevance 0.42 Pain Relevance 0.31
Schild analysis of the interactions of CTP with supraspinal mu and delta agonists in the hot-plate test indicated that although CTP antagonized PL017 in a competitive fashion (Schild slope = -1.0), the interaction of CTP with DPDPE was not competitive (Schild slope = -0.5).
CTP Binding (interaction) of associated with agonist
6) Confidence 0.20 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2886635 Disease Relevance 0 Pain Relevance 0.82
Schild analysis of the interactions of CTP with supraspinal mu and delta agonists in the hot-plate test indicated that although CTP antagonized PL017 in a competitive fashion (Schild slope = -1.0), the interaction of CTP with DPDPE was not competitive (Schild slope = -0.5).
CTP Binding (interactions) of associated with agonist
7) Confidence 0.20 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2886635 Disease Relevance 0 Pain Relevance 1.05
These results indicate that CTP is a selective mu receptor antagonist in vitro.
CTP Binding (indicate) of associated with antagonist
8) Confidence 0.11 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2882015 Disease Relevance 0 Pain Relevance 0.72
Schild analysis of the interactions between CTP and PL017 indicated competitive antagonism between these peptides (Schild slope GPI -0.97 +/- 0.16, Schild slope MVD -1.4 +/- 0.4), and also suggested that the mu receptors in the two tissues are not different (pA2 GPI 7.1 +/- 0.17, pA2 MVD 6.9 +/- 0.16).
CTP Binding (interactions) of in MVD
9) Confidence 0.09 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2882015 Disease Relevance 0 Pain Relevance 0.60

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