INT311229

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DPP4, INS) small molecule metabolic process (INS) Golgi apparatus (DPP4)
endoplasmic reticulum (DPP4) carbohydrate metabolic process (INS) cell-cell signaling (INS)
DPP4 (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 23 48.64 Quite Low
headache 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 1 100.00 Very High Very High Very High
Hypoglycemia 9 86.60 High High
Dementia 1 85.12 High High
Weight Gain 3 79.16 Quite High
Diabetes Mellitus 42 58.68 Quite High
Body Weight 7 34.40 Quite Low
Obesity 4 30.72 Quite Low
Vomiting 8 24.04 Low Low
Weight Loss 8 5.00 Very Low Very Low Very Low
Disease Progression 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combination of metformin with DPP-4 inhibitors combined two synergistic treatment principles, metformin acting on insulin resistance and the DPP-4 inhibitor acting on the glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion (the same synergistic principle of action applies to the combination of a glitazone and a DPP-4 inhibitor).
DPP-4 Positive_regulation (acting) of Gene_expression (resistance) of insulin associated with insulin resistance
1) Confidence 0.32 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2874027 Disease Relevance 0.57 Pain Relevance 0

General Comments

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