INT311254

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.24
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
osteoclasts 4
neurons 1
Acp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 1 91.56 High High
Pain 2 89.28 High High
adenocard 30 88.24 High High
Inflammation 3 84.08 Quite High
Thermal hyperalgesia 2 83.28 Quite High
IPN 4 80.00 Quite High
Neuropathic pain 3 78.24 Quite High
allodynia 1 74.40 Quite High
Lasting pain 2 69.40 Quite High
intrathecal 4 50.40 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 156 99.68 Very High Very High Very High
Nociception 5 98.68 Very High Very High Very High
Pain 4 89.28 High High
INFLAMMATION 3 84.08 Quite High
Hypoxia 1 83.52 Quite High
Hyperalgesia 2 83.28 Quite High
Inflammatory Pain 4 80.00 Quite High
Neuropathic Pain 4 78.24 Quite High
Nervous System Injury 6 64.16 Quite High
Hypercalcemia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A large amount of TRAP enzyme is secreted during osteoclast differentiation.
Localization (secreted) of TRAP enzyme in osteoclast
1) Confidence 0.76 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.52 Pain Relevance 0
TRAP was secreted at the highest levels at day 10 of osteoclast differentiation (Figure 2).
Localization (secreted) of TRAP in osteoclast
2) Confidence 0.76 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.55 Pain Relevance 0
ALP is a biochemical marker of osteoblasts, while TRAP is a biochemical marker of osteoclasts, as the ALP and TRAP enzymes are secreted during osteoblast and osteoclast differentiation, respectively.
Localization (secreted) of TRAP in osteoclasts associated with osteoporosis
3) Confidence 0.76 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.47 Pain Relevance 0
ALP is a biochemical marker of osteoblasts, while TRAP is a biochemical marker of osteoclasts, as the ALP and TRAP enzymes are secreted during osteoblast and osteoclast differentiation, respectively.
Localization (secreted) of TRAP in osteoclasts associated with osteoporosis
4) Confidence 0.71 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.47 Pain Relevance 0
In addition, we observed that NT5E was extensively co-localized with Prostatic acid phosphatase (PAP, also known as ACPP, Fluoride-resistant acid phosphatase or thiamine monophosphatase) in nociceptive neurons.
Localization (localized) of Fluoride-resistant acid phosphatase in neurons associated with nociception
5) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 1.22 Pain Relevance 0.81

General Comments

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