INT311308

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cnbp) endoplasmic reticulum (Cnbp) nucleus (Cnbp)
DNA binding (Cnbp) cytoplasm (Cnbp)
Anatomy Link Frequency
poly 1
muscle 1
Cnbp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 32 82.24 Quite High
Myotonic Dystrophy 44 50.00 Quite Low
Disease 26 50.00 Quite Low
Muscular Atrophy 8 14.32 Low Low
Targeted Disruption 38 8.56 Low Low
Myotonia 28 6.72 Low Low
Congenital Anomalies 22 5.00 Very Low Very Low Very Low
Cataract 14 5.00 Very Low Very Low Very Low
Frailty 14 5.00 Very Low Very Low Very Low
Aging 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding activity of ZNF9 toward the TOP-containing 5’ UTRs is significantly reduced in DM2 muscle.
ZNF9 Binding (binding) of in muscle
1) Confidence 0.32 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.15 Pain Relevance 0
Consistent with this hypothesis, a recent report has shown that ZNF9 interacts with the 5’ UTRs of TOP (terminal oligopyrimidine tract) mRNAs that encode proteins of translational apparatus: human ribosomal protein, RPS17, poly(A)-binding protein, PABP, and elongation factors, eEF1A and eEF2 [96].
ZNF9 Binding (interacts) of in poly
2) Confidence 0.24 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.11 Pain Relevance 0

General Comments

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