INT311309

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
myoblasts 1
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 39 93.92 High High
Frailty 21 90.16 High High
Myotonia 42 88.56 High High
Targeted Disruption 57 87.72 High High
Muscular Atrophy 12 85.00 Quite High
Toxicity 48 69.32 Quite High
Myotonic Dystrophy 66 50.00 Quite Low
Congenital Anomalies 33 5.00 Very Low Very Low Very Low
Cataract 21 5.00 Very Low Very Low Very Low
Aging 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, application of LNA-CAG probe and inclusion of Triton X-100 in the hybridization buffer for detection of mutant DMPK mRNA revealed multiple cytoplasmic aggregates of mutant DMPK mRNA in cytoplasm and in nuclei of DM1 myoblasts (Dr.
Protein_catabolism (aggregates) of mutant DMPK mRNA in myoblasts
1) Confidence 0.67 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
These new data suggest that incomplete degradation of expanded DMPK mRNA and mutant intron 1 of ZNF9 may produce large number of short CUG and CCUG repeats which are toxic products and which may increase the severity of the disease phenotype.
Protein_catabolism (degradation) of DMPK mRNA associated with disease
2) Confidence 0.57 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.55 Pain Relevance 0
No significant changes in the mutant DMPK mRNA stability and polyadenylation have been found [36].
Protein_catabolism (stability) of mutant DMPK mRNA
3) Confidence 0.50 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.07 Pain Relevance 0

General Comments

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