INT311327

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) cytoplasm (Celf1)
Anatomy Link Frequency
myoblasts 1
Celf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 57 80.56 Quite High
Myotonic Dystrophy 66 50.00 Quite Low
Disease 39 50.00 Quite Low
Congenital Anomalies 33 10.80 Low Low
Toxicity 48 5.00 Very Low Very Low Very Low
Myotonia 42 5.00 Very Low Very Low Very Low
Cataract 21 5.00 Very Low Very Low Very Low
Frailty 21 5.00 Very Low Very Low Very Low
Aging 15 5.00 Very Low Very Low Very Low
Muscular Atrophy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the increase of CUGBP1 stability in DM2 patients may be also due to reduced activity of the 20S proteasome.


Protein_catabolism (stability) of CUGBP1
1) Confidence 0.71 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Analysis of CUGBP1 stability in DM2 myoblasts and in normal cells expressing CCUG repeats showed that the stability of CUGBP1 is also increased in the presence of CCUG repeats [52].
Protein_catabolism (stability) of CUGBP1 in myoblasts
2) Confidence 0.53 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.05 Pain Relevance 0
Since CUGBP1 mRNA levels are not increased in DM1 cells, it was suggested that CUG repeats may increase CUGBP1 stability.
Protein_catabolism (stability) of CUGBP1
3) Confidence 0.53 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.08 Pain Relevance 0

General Comments

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