INT311329

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac1) nucleus (Hdac1) enzyme binding (Hdac1)
DNA binding (Hdac1) protein complex (Hdac1) transcription factor binding (Hdac1)
Anatomy Link Frequency
embryos 1
Hdac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 18.08 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 16 79.28 Quite High
Targeted Disruption 19 56.08 Quite High
Myotonic Dystrophy 22 50.00 Quite Low
Disease 13 50.00 Quite Low
Congenital Anomalies 11 47.52 Quite Low
Insulin Resistance 3 28.92 Quite Low
Frailty 7 28.00 Quite Low
INFLAMMATION 1 18.08 Low Low
Myotonia 14 5.00 Very Low Very Low Very Low
Cataract 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although IVM could affect the expression and distribution of GCN5 and HDAC1 in MII oocytes and 2-cell embryos, which might be one reason for the low BR after 2-cell transfer, the levels of acetyl-histone H3 were not significantly changed in IVM group.
Positive_regulation (distribution) of HDAC1 in embryos
1) Confidence 0.19 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
This suggests that elevation of CUGBP1 in DM1 and DM2 patients might increase HDAC1 levels which in turn might alter transcription of many genes.
Spec (might) Positive_regulation (increase) of HDAC1
2) Confidence 0.14 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.14 Pain Relevance 0

General Comments

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