INT311337

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Uts2r) plasma membrane (Uts2r) signal transducer activity (Uts2r)
Anatomy Link Frequency
neurons 1
Uts2r (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 99.22 Very High Very High Very High
cytokine 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 8 99.68 Very High Very High Very High
Targeted Disruption 38 99.04 Very High Very High Very High
Myotonia 28 98.12 Very High Very High Very High
Frailty 15 96.92 Very High Very High Very High
Disease 43 91.44 High High
Arrhythmias 2 Under Development 4 76.16 Quite High
Toxicity 33 70.52 Quite High
Cataract 14 63.72 Quite High
Myotonic Dystrophy 44 50.00 Quite Low
Congenital Anomalies 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the induction of the mutant 3’ UTR of DMPK in mice leads to accumulation of nuclear aggregates and to sequestration of MBNL1; these mice do not show overt DM1 phenotype [34].
Positive_regulation (induction) of UTR
1) Confidence 0.12 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.76 Pain Relevance 0
Elevation of normal 3’ UTR in the DM1 “inducible” transgenic mice caused myotonia, cardiac defects and muscular dystrophy [34].
Positive_regulation (Elevation) of UTR associated with targeted disruption, myotonia and frailty
2) Confidence 0.08 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.59 Pain Relevance 0
Using live-cell imaging, we also examined the localization of transfected RFP-Htt480-17Q and BDNF-3'UTR short mRNA (detected by NLS-MS2-Venus) in cortical neurons (Fig. 2).
Spec (examined) Positive_regulation (transfected) of UTR in neurons associated with imagery
3) Confidence 0.05 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0.05

General Comments

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