INT31134

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 2.51
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
plasma 6
liver 2
erythrocytes 2
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 100.00 Very High Very High Very High
acular 9 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
lidocaine 6 94.88 High High
aspirin 1 82.08 Quite High
ischemia 1 80.72 Quite High
Angina 2 77.12 Quite High
Dopamine 24 75.52 Quite High
agonist 1 66.08 Quite High
Intracerebroventricular 1 52.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 100.00 Very High Very High Very High
Cancer 31 98.60 Very High Very High Very High
Breast Cancer 27 87.84 High High
Disease 17 87.32 High High
Coronary Artery Disease 1 81.60 Quite High
Angina 2 77.12 Quite High
Fatigue 25 75.68 Quite High
Myocardial Infarction 7 75.00 Quite High
Emergencies 1 74.08 Quite High
Aggression 1 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-steroidal anti-inflammatory drugs, fenamates and allylphenyl propionic acids, affected the bilirubin-serum albumin interaction.
Regulation (affected) of serum albumin Binding (interaction) of associated with inflammation and cinod
1) Confidence 0.62 Published 1984 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6714852 Disease Relevance 0.10 Pain Relevance 0.10
Sulfa-drugs, antibiotics, steroidal agents, warfarine, tolubutamide and phenytoin showed no significant effects on the bilirubin-serum albumin interaction.
Neg (no) Regulation (effects) of serum albumin Neg (no) Binding (interaction) of
2) Confidence 0.62 Published 1984 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6714852 Disease Relevance 0.08 Pain Relevance 0.08
In contrast, the binding of albumin-bound drugs diazepam and phenytoin are not affected by these variables.
Neg (not) Regulation (affected) of albumin Binding (binding) of
3) Confidence 0.60 Published 1985 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 3934087 Disease Relevance 0 Pain Relevance 0.35
Effect of different parameters on the binding of two anti-inflammatory drugs to human serum albumin.
Regulation (Effect) of serum albumin Binding (binding) of associated with inflammation and cinod
4) Confidence 0.45 Published 1986 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 3714761 Disease Relevance 0.20 Pain Relevance 0.20
[The effects of various drugs on the binding site of bilirubin in serum albumin].
Regulation (effects) of serum albumin Binding (binding) of
5) Confidence 0.45 Published 1984 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 6714852 Disease Relevance 0.09 Pain Relevance 0.09
Covalent linkage of naproxen to human serum albumin (HSA) has been shown to target it efficiently to the liver and this may potentially be exploited for liver-selective inhibition of angiogenesis.
Regulation (target) of serum albumin Binding (linkage) of in liver
6) Confidence 0.45 Published 2010 Journal Protein Pept. Lett. Section Abstract Doc Link 20214635 Disease Relevance 0.27 Pain Relevance 0.54
Despite their close chemical structures it was shown that the binding of the two compounds to serum albumin, lipoproteins, and erythrocytes was dramatically different both in quality and quantity.
Regulation (different) of serum albumin Binding (binding) of in erythrocytes
7) Confidence 0.45 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2882410 Disease Relevance 0 Pain Relevance 0
Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase.
Regulation (Influence) of albumin Binding (binding) of associated with acular
8) Confidence 0.43 Published 1994 Journal J. Chromatogr. B, Biomed. Appl. Section Title Doc Link 7894686 Disease Relevance 0 Pain Relevance 0.58
Pathological states may affect the binding of drugs to plasma proteins, mainly human serum albumin and alpha 1 acid glycoprotein.
Spec (may) Regulation (affect) of serum albumin Binding (binding) of in plasma
9) Confidence 0.43 Published 1983 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6381335 Disease Relevance 0.29 Pain Relevance 0
The effect of pH and binding of ten physiologically active compounds (isoproterenol, yohimbine, propranolol, clonidine, phenylephrine, carbachol, tripeptide fMLP, diphenhydramine, chlorpromazine and atropine) on the molecular structure of human serum albumin (HSA) has been studied using the dynamic light scattering.
Regulation (effect) of albumin Binding (binding) of associated with clonidine
10) Confidence 0.41 Published 1998 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 9807240 Disease Relevance 0 Pain Relevance 0.15
The influence of the protein (albumin) binding on the pharmacokinetics of these solutes is characterized by the default PKQuest values for KAi in the different organs (Table 6, see Appendix, II and III) and the experimental values for the fraction bound in plasma (fp, Table 1).
Regulation (influence) of albumin Binding (binding) of in plasma
11) Confidence 0.41 Published 2003 Journal BMC Clin Pharmacol Section Body Doc Link PMC194216 Disease Relevance 0 Pain Relevance 0
The exposure of circulating albumin to ischemic tissue alters the ability of albumin to bind cobalt, probably through a mechanism involving free-radical production.
Regulation (alters) of albumin Binding (bind) of
12) Confidence 0.26 Published 2001 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 12213987 Disease Relevance 0.31 Pain Relevance 0.12
Previous studies have demonstrated that elevation in plasma [FFA] displaces Trp from binding to albumin and consequently increases the free-Trp:LNAA ratio into the plasma [17,18,30,31].
Regulation (displaces) of albumin Binding (binding) of in plasma
13) Confidence 0.16 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2896923 Disease Relevance 0.08 Pain Relevance 0.16
Caveolin-2, SPARC, cortactin and dynamin 2 involved in the internalization of albumin may also be important in determining patient response to nab-paclitaxel.32,33
Regulation (involved) of albumin Binding (internalization) of
14) Confidence 0.11 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 1.10 Pain Relevance 0

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