INT311345

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Efemp2) proteinaceous extracellular matrix (Efemp2)
Efemp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 57 98.32 Very High Very High Very High
Disease 39 94.72 High High
Toxicity 48 92.88 High High
Frailty 21 90.16 High High
Myotonia 42 88.56 High High
Muscular Atrophy 12 85.00 Quite High
Cataract 21 56.08 Quite High
Myotonic Dystrophy 66 50.00 Quite Low
Congenital Anomalies 33 5.00 Very Low Very Low Very Low
Aging 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data emphasize that the degradation of the mutant intron 1 of ZNF9 should be carefully examined to identify mechanism regulating its degradation.


Protein_catabolism (degradation) of mutant intron 1
1) Confidence 0.01 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.48 Pain Relevance 0
The aggregation of CCUG repeats in DM2 nuclei suggests that there is a block or delay of the degradation of the mutant intron 1.
Protein_catabolism (degradation) of mutant intron 1
2) Confidence 0.01 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
These new data suggest that incomplete degradation of expanded DMPK mRNA and mutant intron 1 of ZNF9 may produce large number of short CUG and CCUG repeats which are toxic products and which may increase the severity of the disease phenotype.
Protein_catabolism (degradation) of mutant intron 1 associated with disease
3) Confidence 0.00 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.55 Pain Relevance 0

General Comments

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