INT31136

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Context Info
Confidence 0.45
First Reported 1986
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 28
Total Number 33
Disease Relevance 30.76
Pain Relevance 17.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1a) DNA binding (Cacna1a) transmembrane transport (Cacna1a)
cytoplasm (Cacna1a) cell death (Cacna1a) nucleus (Cacna1a)
Anatomy Link Frequency
eye 1
EL4 1
Cacna1a (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 473 100.00 Very High Very High Very High
Migraine 472 100.00 Very High Very High Very High
antagonist 58 100.00 Very High Very High Very High
long-term potentiation 222 99.96 Very High Very High Very High
Calcium channel 21 99.56 Very High Very High Very High
headache 132 99.44 Very High Very High Very High
Inflammation 69 99.38 Very High Very High Very High
agonist 13 99.04 Very High Very High Very High
Morphine 7 98.56 Very High Very High Very High
Neurotransmitter 8 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 301 100.00 Very High Very High Very High
Migraine With Aura 252 100.00 Very High Very High Very High
Death 135 100.00 Very High Very High Very High
Malignant Neoplastic Disease 133 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 26 100.00 Very High Very High Very High
Paresis 5 99.98 Very High Very High Very High
Infarction 1 99.98 Very High Very High Very High
Apoptosis 351 99.96 Very High Very High Very High
Neurologic Manifestations 2 99.96 Very High Very High Very High
Schizophrenia 10 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SCA6 is associated with small expansions of a CAG repeat at the 3' end of the gene, while point mutations are responsible for its two allelic disorders (Episodic Ataxia type 2 and Familial Hemiplegic Migraine).
SCA6 Binding (associated) of associated with ataxia, migraine with aura, migraine and spinocerebellar ataxia type 2
1) Confidence 0.45 Published 2003 Journal Cytogenet. Genome Res. Section Abstract Doc Link 14526175 Disease Relevance 0.90 Pain Relevance 0.14
This case demonstrates the severity possible with a migrainous infarction associated with FHM.
FHM Spec (possible) Binding (associated) of associated with migraine and infarction
2) Confidence 0.41 Published 2004 Journal Headache Section Abstract Doc Link 15447701 Disease Relevance 0.96 Pain Relevance 0.43
Although SCA6 is associated with small expansions of a CAG repeat at the 3?
SCA6 Binding (associated) of
3) Confidence 0.39 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.54 Pain Relevance 0.12
Linkage analysis of these families shows clear linkage to the FHM locus (FHM1) on chromosome 19, supportive linkage to the FHM2 locus whereas no linkage was found to the FHM3 locus.
FHM Spec (clear) Binding (linkage) of associated with migraine
4) Confidence 0.39 Published 2007 Journal Brain Section Abstract Doc Link 17142831 Disease Relevance 1.43 Pain Relevance 1.35
Linkage analysis of these families shows clear linkage to the FHM locus (FHM1) on chromosome 19, supportive linkage to the FHM2 locus whereas no linkage was found to the FHM3 locus.
FHM1 Spec (clear) Binding (linkage) of associated with migraine
5) Confidence 0.39 Published 2007 Journal Brain Section Abstract Doc Link 17142831 Disease Relevance 1.43 Pain Relevance 1.36
Von Brevern et al. [62] however failed to find any CACNA1A, ATP1A2 or SCN1A mutations in patients with migrainous vertigo.
CACNA1A Neg (failed) Binding (find) of associated with vertigo
6) Confidence 0.37 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2276243 Disease Relevance 1.93 Pain Relevance 1.14
We conclude that the SCA6 CAG repeat is not associated with schizophrenia susceptibility.
SCA6 Binding (associated) of associated with schizophrenia
7) Confidence 0.35 Published 1999 Journal Psychiatr. Genet. Section Abstract Doc Link 10412193 Disease Relevance 0.89 Pain Relevance 0.07
Thus, FHM 1, EA2 and SCA6 are all allelic channelopathies, with missense mutations mostly accounting for FHM, mutations disrupting the reading frame for EA2 and polyglutamine expansions in the COOH gene terminal for SCA6.
FHM Binding (accounting) of associated with migraine and channelopathies
8) Confidence 0.32 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2276243 Disease Relevance 2.62 Pain Relevance 1.35
The phenotypic spectrum of the CACNA1A mutations was at first believed to consist either of pure FHM or of FHM associated with cerebellar atrophy.
FHM Binding (associated) of associated with migraine and frailty
9) Confidence 0.31 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2276243 Disease Relevance 2.63 Pain Relevance 1.18
Linkage of FHM to these markers was not formally excluded but seems very unlikely.
FHM Binding (Linkage) of
10) Confidence 0.31 Published 1997 Journal Epilepsia Section Body Doc Link 9579893 Disease Relevance 0.08 Pain Relevance 0
FHM can be associated with other neurological findings including coma and seizures.
FHM Binding (associated) of associated with convulsion and coma
11) Confidence 0.31 Published 2005 Journal Headache Section Abstract Doc Link 16178956 Disease Relevance 0.82 Pain Relevance 0.55
Animal and cellular studies have associated the mutated FHM genes with disturbed ion homeostasis, altered cellular excitability and altered neurotransmitter release.
FHM Binding (associated) of associated with neurotransmitter and migraine
12) Confidence 0.31 Published 2010 Journal Dan Med Bull Section Abstract Doc Link 20816023 Disease Relevance 1.47 Pain Relevance 1.29
The main clinical reason for this validity is that the symptoms of aura and headache are similar, apart from the hemiparesis associated with FHM, and that most patients with FHM also have attacks of common migraine [2].
FHM Binding (associated) of associated with epilepsy, paresis, migraine, headache and migraine without aura
13) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.84 Pain Relevance 1.63
The association of FHM and cerebellar ataxia has been reported in a small number of FHM families, all linked to chromosome 19.
FHM Binding (association) of
14) Confidence 0.20 Published 1999 Journal Neurology Section Body Doc Link 10408534 Disease Relevance 0.19 Pain Relevance 0
Synaptic maturation and elimination at excitatory projections to the LA in Mecp2 deficient mice
LA Binding (maturation) of associated with amygdala
15) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.74
There is considerable clinical variation associated with FHM mutations.
FHM Binding (associated) of
16) Confidence 0.12 Published 2007 Journal J. Hum. Genet. Section Abstract Doc Link 17952365 Disease Relevance 0.32 Pain Relevance 0.26
Considerably increasing the number of mutation carriers with these mutations indicated a clear genotype-phenotype correlation: both mutations are associated with pure FHM.
FHM Binding (associated) of
17) Confidence 0.11 Published 2007 Journal J. Hum. Genet. Section Abstract Doc Link 17952365 Disease Relevance 0.29 Pain Relevance 0.20
As cell membrane integrity is lost during the late phase of apoptosis, cytoplasmic La becomes accessible to binding by specific mAb, which in turn becomes crosslinked in the dying cell by TG2 so that its levels are higher than in dead cells of the counterpart primary cell type [29].
La Binding (binding) of associated with apoptosis
18) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.21 Pain Relevance 0
Our results indicate that the DAB4 mAb, which binds the RNA-binding protein La/SSB, accumulates selectively in tumors after tumor-bearing mice are treated with cytotoxic chemotherapy.
La Binding (binds) of associated with cancer
19) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.19 Pain Relevance 0.03
Studies in EL4 tumor-bearing mice show that, after cytotoxic chemotherapy, binding of this La-specific mAb to tumors was specific and saturable with low accumulation in normal organs [31].
La Binding (binding) of in EL4 associated with cancer
20) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.03 Pain Relevance 0

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