INT311394

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (Celf1) mRNA processing (Celf1) RNA binding (Celf1)
nucleus (Celf1) translation (Eif2s2) cytoplasm (Celf1)
Anatomy Link Frequency
myoblasts 2
muscle 1
Celf1 (Mus musculus)
Eif2s2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
spastic colon 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 114 85.44 High High
Congenital Anomalies 66 79.72 Quite High
Myotonic Dystrophy 132 69.60 Quite High
Disease 78 50.00 Quite Low
Stress 6 49.60 Quite Low
Toxicity 96 5.00 Very Low Very Low Very Low
Myotonia 84 5.00 Very Low Very Low Very Low
Cataract 42 5.00 Very Low Very Low Very Low
Frailty 42 5.00 Very Low Very Low Very Low
Aging 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that the interaction of CUGBP1 with eIF2 is increased during normal muscle differentiation [78].
CUGBP1 Binding (interaction) of eIF2 in muscle
1) Confidence 0.12 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.20 Pain Relevance 0
Interactions of CUGBP1 with eIF2 require site-specific phosphorylation of CUGBP1 at Ser302 by cyclin D3-cdk4 kinase [75,76,78].
CUGBP1 Binding (Interactions) of eIF2
2) Confidence 0.12 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.22 Pain Relevance 0
CUGBP1-dependent activation of translation is mediated by binding of CUGBP1 to mRNAs and to translation initiation eIF2 complex and following delivery of the mRNAs to polysomes [75].
CUGBP1 Binding (binding) of eIF2
3) Confidence 0.08 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.24 Pain Relevance 0
CUGBP1-dependent activation of translation is mediated by binding of CUGBP1 to mRNAs and to translation initiation eIF2 complex and following delivery of the mRNAs to polysomes [75].
CUGBP1 Binding (binding) of eIF2
4) Confidence 0.08 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.24 Pain Relevance 0
Ectopic expression of cyclin D3 promoted the formation of the CUGBP1-eIF2 complex in DM1 myotubes and improved fusion of DM1 myoblasts [78].
CUGBP1 Binding (complex) of eIF2 in myoblasts
5) Confidence 0.08 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.38 Pain Relevance 0
Ectopic expression of cyclin D3 promoted the formation of the CUGBP1-eIF2 complex in DM1 myotubes and improved fusion of DM1 myoblasts [78].
CUGBP1 Binding (complex) of eIF2 in myoblasts
6) Confidence 0.08 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.38 Pain Relevance 0

General Comments

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