INT311438

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 6.56
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (COL13A1) plasma membrane (COL13A1)
Anatomy Link Frequency
thyroid 3
LPS 2
fibroblast 1
immune system 1
connective tissue 1
COL13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 117 99.96 Very High Very High Very High
Pain 9 16.24 Low Low
fibrosis 9 14.00 Low Low
cytokine 27 8.72 Low Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular & Orbital Inflammation 27 99.96 Very High Very High Very High
Thyroid Disease 198 98.02 Very High Very High Very High
Thyroiditis 297 96.58 Very High Very High Very High
Disease 99 94.98 High High
Graves' Ophthalmopathy 279 94.80 High High
Autoimmune Disease 198 93.92 High High
Eyelid Disease 9 93.68 High High
INFLAMMATION 81 84.16 Quite High
Diplopia 18 76.16 Quite High
Muscle Disease 108 75.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Type XIII collagen, expressed in fibroblast cell membranes, is also widely expressed in the adult and developing human eye.36 Although yet to be proven by histological analysis, our findings suggest that chronic UER and lag may reflect autoimmunity against calsequestrin and collagen XIII in the LPS muscle.


Gene_expression (expressed) of Type XIII collagen in LPS associated with autoimmune disease
1) Confidence 0.24 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.24 Pain Relevance 0
Type XIII collagen, expressed in fibroblast cell membranes, is also widely expressed in the adult and developing human eye.36 Although yet to be proven by histological analysis, our findings suggest that chronic UER and lag may reflect autoimmunity against calsequestrin and collagen XIII in the LPS muscle.


Gene_expression (expressed) of Type XIII collagen in LPS associated with autoimmune disease
2) Confidence 0.24 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.28 Pain Relevance 0
The main antibodies proposed are those targeting i) the flavoprotein (Fp) subunit of mitochondrial succinate dehydrogenase; ii) G2s, shown to be a fragment of the FOX-P1 transcription factor; iii) the calcium binding protein calsequestrin; and iv) collagen XIII, a connective tissue antigen expressed in the orbital fibroblast cell membranes.
Gene_expression (expressed) of collagen XIII in fibroblast
3) Confidence 0.24 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.55 Pain Relevance 0
At that time we were also interested in the connective tissue antigen collagen XIII because serum antibodies against collagen XIII were shown to be good markers of ophthalmopathy in patients with active ophthalmopathy.33
Gene_expression (antibodies) of collagen XIII in connective tissue
4) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.59 Pain Relevance 0.04
The orbital antigen, Fp, was also found to be significantly up-regulated, 1.4-fold, while genes encoding collagen XIII, FOXP1/G2s, thyroglobulin, thyroid peroxidise and the TSH-r, were not differentially expressed.48
Neg (not) Gene_expression (expressed.48) of collagen XIII in thyroid
5) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.18 Pain Relevance 0
The prevalences of calsequestrin and collagen XIII antibodies, and to a lesser extent Fp antibodies, were significantly greater in patients with GO compared to healthy controls and in GO patients compared to those with Graves’ hyperthyroidism patients without ophthalmology, which was not the case for antibodies targeting G2s.
Gene_expression (antibodies) of collagen XIII associated with thyroid disease and graves' ophthalmopathy
6) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.84 Pain Relevance 0.04
We postulate that while antibodies directed against the TSH-r may be the initiating event that leads to orbital inflammation, collagen XIII is also good candidate antigen in the congestive subtype of TAO as it has been shown to be expressed in the plasma membrane of orbital fibroblasts, and thus accessible to the immune system.
Gene_expression (expressed) of collagen XIII in immune system associated with inflammation and ocular & orbital inflammation
7) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.67 Pain Relevance 0.09
To further characterize the mechanism for chronic eyelid disease we carried out a similar study in patients with; Graves’ disease with UER as a dominant feature of their ophthalmopathy, Hashimoto’s thyroiditis with UER as an isolated abnormality and non-immunologic thyroid disease associated with UER.36 We found a generally good correlation between the prevalence of antibodies targeting calsequestrin and collagen XIII and the severity of UER in these patient groups.
Gene_expression (targeting) of collagen XIII in thyroid associated with thyroiditis, eyelid disease, thyroid disease, graves' ophthalmopathy and disease
8) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.03 Pain Relevance 0
The orbital antigen, Fp, was also found to be significantly up-regulated, 1.4-fold, while genes encoding collagen XIII, FOXP1/G2s, thyroglobulin, thyroid peroxidise and the TSH-r, were not differentially expressed.48
Gene_expression (encoding) of collagen XIII in thyroid
9) Confidence 0.21 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.18 Pain Relevance 0

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