INT311441

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.00 Pain Relevance 0.04

cell differentiation (COL13A1) plasma membrane (COL13A1)

Anatomy Link Frequency fibroblast 1 connective tissue 1 COL13A1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 26 87.04 Pain 2 13.12 cytokine 6 5.00 fibrosis 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Autoimmune Disease 44 89.16 Disease 22 87.80 Graves' Ophthalmopathy 62 87.44 INFLAMMATION 18 87.04 Myasthenia Gravis 2 70.56 Thyroid Disease 44 56.84 Muscle Disease 24 52.56 Thyroiditis 66 38.84 Hyperthyroidism 8 34.96 Pressure And Volume Under Development 4 33.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The main antibodies proposed are those targeting i) the flavoprotein (Fp) subunit of mitochondrial succinate dehydrogenase; ii) G2s, shown to be a fragment of the FOX-P1 transcription factor; iii) the calcium binding protein calsequestrin; and iv) collagen XIII, a connective tissue antigen expressed in the orbital fibroblast cell membranes.

collagen XIII Binding (binding) of in fibroblast

1) Confidence 0.11 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.45 Pain Relevance 0

At that time we were also interested in the connective tissue antigen collagen XIII because serum antibodies against collagen XIII were shown to be good markers of ophthalmopathy in patients with active ophthalmopathy.33

collagen XIII Binding (interested) of in connective tissue

2) Confidence 0.10 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.55 Pain Relevance 0.04

General Comments

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