INT311447

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.24 Pain Relevance 0.08

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)

Anatomy Link Frequency eye 4 TSHR (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 26 62.96 cytokine 6 5.00 fibrosis 2 5.00 Pain 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Thyroiditis 66 100.00 Graves' Ophthalmopathy 62 100.00 Disease 22 100.00 Obesity 2 100.00 Thyroid Disease 44 99.24 Hyperthyroidism 8 98.00 Autoimmune Disease 44 86.88 Hypothyroidism 2 74.04 INFLAMMATION 18 62.96 Muscle Disease 24 59.28

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, the TSH-r is also expressed in fibroblasts and adipocytes at sites such as the abdominal wall which are unaffected in Graves’ disease patients.16 In patients with Hashimoto’s thyroiditis, eye changes occur in the presumed absence of TSH-r antibody production.

Negative_regulation (absence) of Gene_expression (expressed) of TSH-r in eye associated with thyroiditis, graves' ophthalmopathy, obesity and disease

1) Confidence 0.39 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.18 Pain Relevance 0.06

Furthermore, the TSH-r is also expressed in fibroblasts and adipocytes at sites such as the abdominal wall which are unaffected in Graves’ disease patients.16 In patients with Hashimoto’s thyroiditis, eye changes occur in the presumed absence of TSH-r antibody production.

Negative_regulation (absence) of Gene_expression (production) of TSH-r in eye associated with thyroiditis, graves' ophthalmopathy, obesity and disease

2) Confidence 0.39 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.06 Pain Relevance 0.03

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