INT311452

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Context Info
Confidence 0.74
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 7.58
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CASQ1) Golgi apparatus (CASQ1) endoplasmic reticulum (CASQ1)
cytoplasm (CASQ1)
Anatomy Link Frequency
thyroid 3
skeletal muscle 3
eye muscle 1
fibroblast 1
levator palpebrae superioris 1
CASQ1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 130 94.36 High High
Pain 10 16.24 Low Low
cytokine 30 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 220 98.02 Very High Very High Very High
Thyroiditis 330 97.64 Very High Very High Very High
Autoimmune Disease 220 97.08 Very High Very High Very High
Disease 110 94.98 High High
Graves' Ophthalmopathy 310 94.80 High High
INFLAMMATION 90 94.36 High High
Eyelid Disease 10 93.68 High High
Muscle Disease 120 92.44 High High
Myasthenia Gravis 10 90.72 High High
Ocular & Orbital Inflammation 30 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, like skeletal muscle calsequestrin, cardiac muscle calsequestrin is also expressed more in the eye muscle than other skeletal muscle, 2.7-fold.49 The finding that the CASQ2 gene was the most highly upregulated gene in thyroid tissue from patients with GO is unlikely to be a chance finding.
Gene_expression (expressed) of calsequestrin in skeletal muscle
1) Confidence 0.74 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.11 Pain Relevance 0
It is clear that calsequestrin genes are not supposed to be expressed in the thyroid gland and their up-regulation in the thyroid of patients with ophthalmopathy provides further support for a role of autoimmunity against calsequestrin in its pathogenesis.
Gene_expression (expressed) of calsequestrin in thyroid associated with autoimmune disease
2) Confidence 0.74 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.16 Pain Relevance 0
Interestingly, like skeletal muscle calsequestrin, cardiac muscle calsequestrin is also expressed more in the eye muscle than other skeletal muscle, 2.7-fold.49 The finding that the CASQ2 gene was the most highly upregulated gene in thyroid tissue from patients with GO is unlikely to be a chance finding.
Gene_expression (expressed) of calsequestrin in skeletal muscle
3) Confidence 0.74 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.11 Pain Relevance 0
This may be initiated in the thyroid where calsequestrin expression is upregulated, possibly due to a stimulatory effect of TSH-r antibodies.
Gene_expression (expression) of calsequestrin in thyroid
4) Confidence 0.74 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2874268 Disease Relevance 0.79 Pain Relevance 0.03
Calsequestrin is highly expressed in the EOM32 including, presumably, the levator palpebrae superioris (LPS) muscle.
Gene_expression (expressed) of Calsequestrin in levator palpebrae superioris
5) Confidence 0.74 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.08 Pain Relevance 0
Calsequestrin and Fp antibodies were the most frequently detected and collagen XIII antibodies were detected in only two patients with ST and one patient with Hashimoto’s thyroiditis.5 These findings suggest that ophthalmopathy associated with destructive thyroiditis is mainly an eye muscle disorder.
Gene_expression (detected) of Calsequestrin in eye muscle associated with thyroiditis and muscle disease
6) Confidence 0.64 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 2.11 Pain Relevance 0.03
To further characterize the mechanism for chronic eyelid disease we carried out a similar study in patients with; Graves’ disease with UER as a dominant feature of their ophthalmopathy, Hashimoto’s thyroiditis with UER as an isolated abnormality and non-immunologic thyroid disease associated with UER.36 We found a generally good correlation between the prevalence of antibodies targeting calsequestrin and collagen XIII and the severity of UER in these patient groups.
Gene_expression (targeting) of calsequestrin in thyroid associated with thyroiditis, eyelid disease, thyroid disease, graves' ophthalmopathy and disease
7) Confidence 0.64 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.97 Pain Relevance 0
When Porter et al32 showed that calsequestrin was expressed 4.8 times more in eye muscle compared to other skeletal muscle, thus offering an explanation for the orbital specificity of skeletal muscle inflammation in Graves’ disease, we decided to re visit its possible role in the pathogenesis of TAO.
Gene_expression (expressed) of calsequestrin in skeletal muscle associated with inflammation, graves' ophthalmopathy and disease
8) Confidence 0.57 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.85 Pain Relevance 0.05
The main antibodies proposed are those targeting i) the flavoprotein (Fp) subunit of mitochondrial succinate dehydrogenase; ii) G2s, shown to be a fragment of the FOX-P1 transcription factor; iii) the calcium binding protein calsequestrin; and iv) collagen XIII, a connective tissue antigen expressed in the orbital fibroblast cell membranes.
Gene_expression (expressed) of calsequestrin in fibroblast
9) Confidence 0.56 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.56 Pain Relevance 0
The prevalences of calsequestrin and collagen XIII antibodies, and to a lesser extent Fp antibodies, were significantly greater in patients with GO compared to healthy controls and in GO patients compared to those with Graves’ hyperthyroidism patients without ophthalmology, which was not the case for antibodies targeting G2s.
Gene_expression (antibodies) of calsequestrin associated with thyroid disease and graves' ophthalmopathy
10) Confidence 0.56 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.84 Pain Relevance 0.04

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